Handbook of Evidence-Based Radiation Oncology

Building on the success of this book's first edition, Dr. Eric Hansen and Dr. Mack Roach have updated, revised, and expanded the Handbook of Evidence-based Radiation Oncology, a portable reference that utilizes evidence-based medicine as the basis fo

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Handbook of Evidence-Based Radiation Oncology 2nd Edition Eric K. Hansen, MD

The Oregon Clinic Radiation Oncology Providence St. Vincent Medical Center Portland, Oregon, USA

Mack Roach, III, MD, FACR

Professor, Radiation Oncology and Urology Chair, Department of Radiation Oncology UCSF Helen Diller Family Comprehensive Cancer Center University of California San Francisco San Francisco, California, USA

Dr. Eric K. Hansen The Oregon Clinic, Providence St. Vincent Medical Center, Portland, OR, USA e-mail: [email protected] Dr. Mack Roach III University of California, San Francisco, CA, USA e-mail: [email protected]

ISBN: 978-0-387-92987-3     e-ISBN: 978-0-387-92988-0 DOI: 10.1007/978-0-387-92988-0 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2009942763 © Springer Science+Business Media, LLC 2010 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is ­concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant ­protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover designer: Joe Piliero Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

Dedication

To Keith Hansen – Compassionate and dedicated physician; loving husband, father, and grandfather. You were larger than life!

Preface to the 2nd Edition

The first edition of Handbook of Evidence-Based Radiation Oncology was extremely successful and well received by the worldwide oncology community. In the second edition, we have kept the same concise format in order to remain a practical quick reference guide. Yet we have also added new content and features based on the valuable feedback from readers. All chapters have been revised and include the latest key studies and radiotherapy techniques. Color figures are included for the first time. Three new chapters have been written, including management of the neck and unknown ­primary of the head and neck, urethral cancer, and clinical ­radiobiology and physics. An appendix on use of IV contrast has been added as well. We are particularly pleased that our second edition includes the newly published 2010 AJCC and 2