Has the Outcome for Patients Who Undergo Resection of Primary Retroperitoneal Sarcoma Changed Over Time? A Study of Time
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ORIGINAL ARTICLE – SARCOMA
Has the Outcome for Patients Who Undergo Resection of Primary Retroperitoneal Sarcoma Changed Over Time? A Study of Time Trends During the Past 15 years Dario Callegaro, MD1,2,3, Chandrajit P. Raut, MD, MSc4, Deanna Ng, MD1,2, Dirk C. Strauss, MD5, Charles Honore´, MD, PhD6, Eberhard Stoeckle, MD7, Sylvie Bonvalot, MD, PhD8, Rick L. Haas, MD, PhD9, Nikolaos Vassos, MD5,10, Lorenzo Conti, MD3, Rebecca A. Gladdy, MD, PhD1,2, Mark Fairweather, MD4, Winan van Houdt, MD, PhD, MSc11, Yvonne Schrage, MD11,12, Frits van Coevorden, MD, PhD11, Piotr Rutkowski, MD, PhD13, Rosalba Miceli, PhD14, Alessandro Gronchi, MD3, and Carol J. Swallow, MD, PhD1,2 1
Department of Surgical Oncology, Princess Margaret Cancer Centre/Mount Sinai Hospital, Toronto, Canada; 2Department of Surgery, University of Toronto, Toronto, ON, Canada; 3Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; 4Department of Surgery, Dana-Farber Cancer Institute, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA; 5Sarcoma Unit, Department of General Surgery, Royal Marsden NHS Foundation Trust, London, UK; 6Department of Surgery, Institut Gustave Roussy, Villejuif, France; 7Surgery, Institut Bergonie´, Bordeaux, France; 8Department of Surgery, Institut Curie, Paris, France; 9Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands; 10Division of Surgical Oncology, Department of Surgery, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany; 11Department of Surgical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands; 12Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands; 13Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland; 14Department of Clinical Epidemiology and Trial Organisation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
ABSTRACT Background. This study aimed to investigate changes in treatment strategy and outcome for patients with primary retroperitoneal sarcoma (RPS) undergoing resection at referral centers during a recent period. Methods. The study enrolled consecutive adult patients with primary non-metastatic RPS who underwent resection
Presented in part at the Society of Surgical Oncology 2019 Annual Cancer Symposium, 28 March, 2019, San Diego, CA, USA.
Electronic supplementary material The online version of this article (https://doi.org/10.1245/s10434-020-09065-6) contains supplementary material, which is available to authorized users. Society of Surgical Oncology 2020 First Received: 14 June 2020 Accepted: 9 August 2020 C. J. Swallow, MD, PhD e-mail: [email protected]
with curative intent between 2002 and 2017 at 10 referral centers. The patients were grouped into three periods according to date of surgery: t1 (2002–2006), t2 (2007–2011), and t3 (2012–2017). Five-year overall survival (OS), disease-specific survival (DSS), and crude cumulative incide
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