Health-related quality of life of Southern Chinese with chronic hepatitis B infection
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BioMed Central
Open Access
Research
Health-related quality of life of Southern Chinese with chronic hepatitis B infection Elegance TP Lam*1, Cindy LK Lam1, CL Lai2, MF Yuen2, Daniel YT Fong3 and Thomas MK So4 Address: 1Department of Medicine (Family Medicine Unit), The University of Hong Kong, 3/F, 161 Main Street, Ap Lei Chau Clinic, Ap Lei Chau, Hong Kong, 2Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 3Department of Nursing Studies, The University of Hong Kong, 4/F, William MW Mong Block, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong and 4Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong Email: Elegance TP Lam* - [email protected]; Cindy LK Lam - [email protected]; CL Lai - [email protected]; MF Yuen - [email protected]; Daniel YT Fong - [email protected]; Thomas MK So - [email protected] * Corresponding author
Published: 5 June 2009 Health and Quality of Life Outcomes 2009, 7:52
doi:10.1186/1477-7525-7-52
Received: 22 December 2008 Accepted: 5 June 2009
This article is available from: http://www.hqlo.com/content/7/1/52 © 2009 Lam et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Few studies have evaluated the health-related quality of life (HRQOL) of Southern Chinese with chronic hepatitis B (CHB) infection. Aim: To evaluate the HRQOL of Chinese patients at different stages of CHB infection and to find out factors associated with HRQOL. Methods: 520 Chinese adult CHB patients of whom 156 were uncomplicated, 102 had impaired liver function, 139 had cirrhosis and 123 had hepatocellular carcinoma (HCC) were interviewed with a structured questionnaire, the SF-36 Health Survey version 2 (SF-36v2), and the Chronic Liver Disease Questionnaire (CLDQ). The differences in SF-6D health preference values and SF36v2 scores between each CHB group and Hong Kong population norms were assessed by t-test. ANOVA was used to compare the mean SF-6D health preference, SF-36v2 scores, and CLDQ scores among CHB groups. Multiple linear regressions were performed to identify determinants of HRQOL. Results: CHB patients had significantly lower SF-36v2 scores than the population norm. The SF6D values of CHB patients with uncomplicated disease, impaired liver function, HCC and cirrhosis were 0.755, 0.745, 0.720 and 0.701, respectively, all significantly lower than the population norm of 0.787. Advanced stage of CHB illness, anti-viral treatment, bilirubin level, psychological comorbidity, younger age and female were associated with poorer HRQOL. Conclusion: CHB infection had a negative impact on HRQOL. There was a progressive decrease in health preference values with CHB disease progression. The results can be used for the estimation of quality adjusted life years (QALYs) for CHB patients in cost e
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