Heart Failure Prevention: Special Considerations for Women

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HEART FAILURE PREVENTION (W TANG, SECTION EDITOR)

Heart Failure Prevention: Special Considerations for Women Rebecca Chester 1 & Marcella Calfon Press 2 & Tamara B. Horwich 3

Published online: 5 February 2016 # Springer Science+Business Media New York 2016

Abstract Heart failure (HF) is a growing epidemic in the USA, and the American Heart Association estimates there are 550,000 new cases of HF in men and women annually. Despite advances in evidence-based cardiovascular care including improved awareness of women’s cardiovascular disease, important gender discrepancies persist in the diagnosis and management of HF. Coronary heart disease (CHD) is a leading cause of HF in the USA, and despite advancing therapies for acute coronary syndromes, young women (age < 55) are the only population with increasing mortality from CHD. Women stand to greatly benefit from improved efforts targeting HF prevention; therefore, the purposes of this paper are to review the current literature pertaining to HF prevention in women and to identify areas where opportunities exist for improving cardiovascular care for women as well as topics that warrant further investigation.

This article is part of the Topical Collection on Heart Failure Prevention * Tamara B. Horwich [email protected] Rebecca Chester [email protected] Marcella Calfon Press [email protected]

1

Department of Medicine, UCLA, 757 Westwood Plaza, Suite 7501, Los Angeles, CA 90095, USA

2

Division of Cardiology, UCLA, 100 Medical Plaza Suite 630 West, Los Angeles, CA 90095, USA

3

Division of Cardiology, UCLA, 10833 Le Conte Ave CHS A2-237, Los Angeles, CA 90095, USA

Keywords Women . Heart failure . Prevention . Cardiovascular disease . Sex . Coronary artery disease . Hypertension . Diabetes . Gestational diabetes . Obesity . Metabolic syndrome . Statins . Cholesterol . Lifestyle . Heart failure preserved ejection fraction

Introduction Heart failure (HF) is a growing epidemic in the USA and is an urgent public health threat. The American Heart Association estimates there are 550,000 new cases of HF annually, and once HF develops, only 50 % of patients will survive to 5 years after diagnosis, a prognosis more dire than most cancers. Heart disease is more prevalent in women compared to men, and furthermore, heart disease is the number one killer of women in the USA [1]. Attention to gender differences in cardiovascular disease is critical to improving outcomes for women with cardiovascular disease and also critical to preventing cardiovascular disease such as HF in women. HF is a growing epidemic for both men and women; both sexes have a 20 % lifetime risk of developing HF. Despite a similar lifetime risk, important gender differences in HF exist. Women with HF are typically older and have more co-morbid medical conditions compared to men. Gender discrepancies exist in treatment of those at risk of HF, including less frequent revascularization in women with acute coronary syndromes (ACS), underutilization of evidence-based therapies in women, an