Hematological Disorders in Children Pathogenesis and Treatment
This book describes the pathogenesis and treatment of several representative hematological disorders in children, with a special focus on genetic and molecular aspects. Research on the pathogenesis of hematological disorders in children has made remarkabl
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Hematological Disorders in Children Pathogenesis and Treatment
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Hematological Disorders in Children
Eiichi Ishii Editor
Hematological Disorders in Children Pathogenesis and Treatment
Editor Eiichi Ishii Department of Pediatrics Ehime University Graduate School of Medicine Toon, Ehime Japan
ISBN 978-981-10-3885-3 ISBN 978-981-10-3886-0 (eBook) DOI 10.1007/978-981-10-3886-0 Library of Congress Control Number: 2017943113 © Springer Nature Singapore Pte Ltd. 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Preface
In recent years, the pathogenesis of hematological disorders in children has been clarified, which has led to remarkable progress in the treatment outcome for these disorders. In particular, molecular targeted therapy has been shown to have an effect on childhood leukemia refractory to conventional therapy. Further development of these strategies will enable us to use more effective and less toxic therapies for hematological disorders in the future. Here we describe the pathogenesis and treatment (present and future) of several representative hematological disorders in children, especially focusing on the genetic and molecular aspects. Most hematological disorders in children arise from intrauterine endogenous or exogenous exposures, genetic susceptibility, or several factors after birth. A good example is the case of infant leukemia. Greaves et al. [1] clarified the etiology of infant leukemia; analysis of MLL gene rearrangements in identical leukemic twins suggested that the MLL gene undergoes prenatal rearrangement and leukemic cells are present in the blood of newborns. In utero exposure
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