Hepatic De Novo Lipogenesis and Regulation of Metabolism
The liver is the largest solid vital organ in mammals that supports other organ in the body in some facet. This book synthesizes all the primary and relevant metabolic information that one needs to review to understand the complex and diverse role o
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Hepatic De Novo Lipogenesis and Regulation of Metabolism
Hepatic De Novo Lipogenesis and Regulation of Metabolism
James M. Ntambi Editor
Hepatic De Novo Lipogenesis and Regulation of Metabolism
Editor James M. Ntambi Department of Biochemistry University of Wisconsin-Madison Madison, WI, USA
ISBN 978-3-319-25063-2 ISBN 978-3-319-25065-6 DOI 10.1007/978-3-319-25065-6
(eBook)
Library of Congress Control Number: 2015956534 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
Preface
The liver is the largest solid vital organ in mammals that supports other organs in the body in some facet. Without a healthy liver, a person cannot survive. In the human it is located in the upper right quadrant of the abdomen, below the diaphragm. This book constitutes an effort to sum-up all the primary and relevant metabolic information that one needs to review to understand the complex and diverse role of the liver in metabolism. With the current epidemic of metabolic diseases, it is of immediate importance to understand the contribution of the liver in health and its role in the development of impaired metabolic regulation. Many studies have unmasked important roles that proteins expressed in the liver play in the development of or protection from metabolic diseases. Obesity is currently a worldwide public health burden that increases the risk for developing insulin resistance and several metabolic diseases such as diabetes, cardiovascular disease, inflammation and non-alcoholic fatty liver disease. Dietary approaches to limit fat intake are commonly prescribed to achieve the hypocaloric conditions necessary for weight loss. But dietary fat restriction is often accompanied by increased carbohydrate intake, which can dramatically increase endogenous f
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