Hepatotoxic effects caused by simultaneous exposure to noise and toluene in New Zealand white rabbits: a biochemical and
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Hepatotoxic effects caused by simultaneous exposure to noise and toluene in New Zealand white rabbits: a biochemical and histopathological study Amirreza Abouee-Mehrizi
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Yahya Rasoulzadeh2 Ahmad Mehdipour3 Alireza Alihemmati4 Elnaz Rahimi1,2 ●
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Accepted: 6 October 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract The aim of this experimental study was to investigate hepatotoxicity effects of noise and toluene, and in particular, to study hepatotoxicity effects of simultaneous exposure to noise and toluene by histopathological and biochemical experiments. To experiment hepatotoxicity effects of noise and toluene, 100 dB white noise and 1000 ppm toluene vapors were generated during two consecutive weeks in healthy male New Zealand White rabbits. Non-simultaneous exposure to noise and toluene increased liver enzymes and the serum levels of superoxide dismutase, malondialdehyde, and total antioxidant capacity, and also decreased serum level of glutathione peroxidase. Alanine transaminase, aspartate transaminase, gamma-glutamyl transferase, malondialdehyde, total antioxidant capacity, and superoxide dismutase levels increased by simultaneous exposure to noise and toluene. Furthermore, catalase and alkaline phosphatase level decreased by simultaneous exposure to noise and toluene. The hematoxylin and eosin stain (H&E) experiments indicated significant swelling, lipidosis, eosinophilic cytoplasm, pyknosis, karyorrhexis, and disruption of the cytoplasmic membrane in the liver tissue due to exposure to noise, toluene and simultaneous exposure to them. Graphical Abstract
Keywords Ecotoxicology Industrial pollution Occupational health Liver Hepatotoxicity Oxidative stress ●
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Supplementary information The online version of this article (https:// doi.org/10.1007/s10646-020-02288-z) contains supplementary material, which is available to authorized users. * Yahya Rasoulzadeh [email protected]
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Department of Tissue Engineering, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
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Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
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Department of Occupational Health Engineering, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran
A. Abouee-Mehrizi et al.
Introduction Noise is a physical phenomenon which is irregular, unpleasant, and unwanted and is caused by changes in air pressure (Wang et al. 2010). Noise pollution is a major problem in urban environments and affects human behavior, well-being, and productivity (Wang et al. 2010). Furthermore, the production of loud and excessive environmental noise has widespread effects animals, such as changing the behavior of animals and their migration and even reducing fertility and increasing the risk of their extinction (Yong 2008). Some previous studies showed that exposure to high level of noise cause
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