Hereditary Colorectal Cancer
Early detection of colorectal cancers is a significant and relatively recent achievement. Persons who carry genetic mutations linked to hereditary colorectal cancer make up 20% of the patient population. With the advent of molecular genetics and the descr
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M.D. ANDERSON SOLID TUMOR ONCOLOGY SERIES Series Editor: Raphael E. Pollock, M.D., Ph.D.
For other titles published in this series, go to www.springer.com/series/3833
Miguel A. Rodriguez-Bigas • Raul Cutait Patrick M. Lynch • Ian Tomlinson Hans F.A. Vasen Editors
Hereditary Colorectal Cancer
Editors Miguel A. Rodriguez-Bigas, MD Professor of Surgery The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Blvd Houston, TX 77030 USA [email protected] Raul Cutait, MD Associate Professor of Surgery University of São Paulo Medical School Director, Brazilian Registry of Inherited Colorectal Cancer Sao Paulo, Brazil
Patrick M. Lynch, MD University of Texas MD Anderson Cancer Center 1515 Holcombe Blvd Houston, TX 77030 USA Ian Tomlinson, MD Molecular and Population Genetics Laboratory Cancer Research UK London Research Institute London, UK
Hans F.A. Vasen, MD The Netherlands Foundation for the Detection of Hereditary Tumours Leiden University Medical Centre (Poortgebouw) Rijnsburgerweg 10 2333 AA Leiden The Netherlands
ISBN 978-1-4419-6602-5 e-ISBN 978-1-4419-6603-2 DOI 10.1007/978-1-4419-6603-2 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010933974 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Cover illustration: Image by Sebastian Kaulitzki Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Over the last quarter of a century, significant and explosive advancements have been made regarding the study of colorectal cancer. The wealth of information evolving is far reaching. From the first case report of the loss of the long arm of chromosome 5 in a patient with Familial Adenomatous Polyposis, to the cloning and identification of multiple genes involved in hereditary colorectal cancer, the field has progressed so we can now offer our patients genetic predisposition testing and better clinical management. Molecular mechanisms and the implicat
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