Hereditary Peripheral Neuropathies
"Hereditary Peripheral Neuropathies" deals with the Charcot-Marie-Tooth group of neuropathies and related primary hereditary neuropathies. The knowledge in this field has grown exponentially during the last ten years. The book is divided into two sections
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Hereditary Peripheral Neuropathies
G. Kuhlenbåumer F. Stægbauer E. B. Ringelstein P. Young (Eds.)
Hereditary Peripheral Neuropathies With 32 Figures and 20 Tables
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Priv.-Doz. Dr. Gregor Kuhlenbåumer Leibniz Institute for Atherosclerosis Research Department of Neurology University of Mçnster Albert-Schweitzer-Str. 33 48129 Mçnster Germany Prof. Dr. E. Bernd Ringelstein Leibniz Institute for Atherosclerosis Research Department of Neurology University of Mçnster Albert-Schweitzer-Str. 33 48129 Mçnster Germany
Prof. Dr. Florian Stægbauer Department of Neurology Klinikum Osnabrçck Am Finkenhçgel 49076 Osnabrçck Germany Dr. Peter Young Department of Neurology University of Mçnster Albert-Schweitzer-Str. 33 48129 Mçnster Germany
ISBN 3-7985-1453-4 Steinkopff Verlag Darmstadt Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the Internet at . This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Steinkopff Verlag Darmstadt a member of Springer Science+Business Media www.steinkopff.springer.de ° Steinkopff Verlag Darmstadt 2005 Printed in Germany The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about the application of operative techniques and medications contained in this book. In every individual case the user must check such information by consulting the relevant literature. Production: Klemens Schwind Cover Design: Erich Kirchner, Heidelberg Typesetter: K+V Fotosatz GmbH, Beerfelden SPIN 10925485
80/7231-5 4 3 2 1 0 ± Printed on acid-free paper
Preface
Hereditary peripheral neuropathies are the most common inherited diseases of the nervous system. The high prevalence of 1 patient per 2500 inhabitants underscores the importance of these diseases in everyday clinical practice. Until the 1990s, the diagnosis of hereditary peripheral neuropathies was based on clinical findings alone. Very little was known about the various entities, their diagnostic differentiation, their natural course or biological background. This is why a firm diagnosis could often not be made. The advent of positional cloning opened up a completely new avenue for the identifica
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