Herpes Simplex Virus
Epidermal intracytoplasmic edema, acantholysis, vesicle formation, and/or necrosis
- PDF / 274,739 Bytes
- 2 Pages / 595.28 x 790.87 pts Page_size
- 18 Downloads / 225 Views
Herpes Simplex Virus
• Epidermal intracytoplasmic edema, acantholysis, vesicle formation, and/or necrosis – Acanthosis can be seen in chronic lesions • Dermal lymphohistiocytic inflammatory infiltrate • Follicular involvement and vasculitis can be seen • Can detect viral particles by electron microscopy
• Multinucleated cells with ground-glass nuclear inclusions, nuclear molding, and margination of chromatin – Cowdry bodies = eosinophilic nuclear inclusions composed of nucleic acid and protein • Type A = with surrounding halo, “owl-eye” • Type B = fills nucleus
Fig. 6.1 Herpes Simplex. Epidermal keratinocytes infected with herpes virus display finely dispersed nuclear chromatin, nuclear inclusions and multinucleate cells
14
K.S. Masterpol et al., Atlas of Essential Dermatopathology, DOI 10.1007/978-1-4471-4471-7_6, © Springer-Verlag London 2013
6
Herpes Simplex Virus
15
Fig. 6.2 Sketch of viral cytopathic effect of herpes virus infection. Keratinocytes may display bright pink intranuclear inclusions, dispersion of nuclear chromatin with molding of the nuclei to one another, and multinucleate cells. The viral particles have characteristic capsid and surrounding envelope
Nuclear Inclusions
Nuclear Molding
Multinucleated Cells
Viral Particles by Electron Microscopy
Data Loading...
