Heterogeneity in Asthma
Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens represent
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Allan R. Brasier Editor
Heterogeneity in Asthma
Advances in Experimental Medicine and Biology Editorial Board: IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy
For further volumes: http://www.springer.com/series/5584
Allan R. Brasier Editor
Heterogeneity in Asthma
Editor Allan R. Brasier, M.D. Institute for Translational Sciences University of Texas Medical Branch Galveston, TX, USA
ISSN 0065-2598 ISSN 2214-8019 (Electronic) ISBN 978-1-4614-8602-2 ISBN 978-1-4614-8603-9 (eBook) DOI 10.1007/978-1-4614-8603-9 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2013952908 © Springer Science+Business Media New York 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface Application of Translational Science to the Clinical Problem of Asthma
The Problem Asthma is a chronic relapsing airways disease that represents one of the most common chronic diseases worldwide (Busse et al. 2001; Masoli et al. 2004). Currently it is estimated that over 300 M people suffer from asthma, and its prevalence is increasing in both a
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