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Vaccine failure: 14 case reports A study of 31 patients conducted from 1 January 2012 to 31 December 2018 in Italy, described 14 patients including 8 male patients and 6 female patients aged between 7 months–13 years, who experienced vaccine failure following administration of Hibvaccine conjugate given for invasive Haemophilus influenza disease. The patients received Hib-vaccine conjugate at the age range between 2–13 months [routes not stated]. The patients received 2 or 3 doses of Hib-vaccine conjugate. However, the patients experienced vaccine failure and developed Haemophilus influenzae serotype b (Hib) infection which leading cause bacteraemia, sepsis and meningitis (one patient), meningitis (five patients), epiglottitis (one patient), bacteremic pneumonia (three patients) and bacteraemia and sepsis (four patients) in between January 2013–November 2018. Interval between the last vaccine and disease onset were in the range between 3 months–12 years. Additionally, the patients received the hexavalent diphtheria vaccine, tetanus vaccine and Hib-DTP-hepatitis-B-poliovirus-vaccine [acellular pertussis-hepatitis B virus inactivated polio virus/Hib vaccine; DTPa-HBV-IPV/Hib vaccines]. Out of the 14 patients, 12 patients survived with no sequelae. Out of the remaining 2 patient one survived and other was noted deceased. Giufre M, et al. Invasive Haemophilus influenzae type b (Hib) disease in children in Italy, after 20 years of routine use of conjugate Hib vaccines. Vaccine 38: 6533-6538, No. 803518414 42, 29 Sep 2020. Available from: URL: http://doi.org/10.1016/j.vaccine.2020.08.022

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Reactions 5 Dec 2020 No. 1833