High ceruloplasmin levels are associated with obsessive compulsive disorder: a case control study
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BioMed Central
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High ceruloplasmin levels are associated with obsessive compulsive disorder: a case control study Osman Virit1, Salih Selek*2, Mahmut Bulut1, Haluk Asuman Savas1, Hakim Celik3, Ozcan Erel3 and Hasan Herken4 Address: 1Department of Psychiatry, Medical Faculty, Gaziantep University, Gaziantep, Turkey, 2Department of Psychiatry, Kahramanmaras State Hospital, Kahramanmaras, Turkey, 3Department of Clinical Biochemistry, Medical Faculty, Harran University, Sanliurfa, Turkey and 4Department of Psychiatry, Medical Faculty, Pamukkale University, Denizli, Turkey Email: Osman Virit - [email protected]; Salih Selek* - [email protected]; Mahmut Bulut - [email protected]; Haluk Asuman Savas - [email protected]; Hakim Celik - [email protected]; Ozcan Erel - [email protected]; Hasan Herken - [email protected] * Corresponding author
Published: 18 November 2008 Behavioral and Brain Functions 2008, 4:52
doi:10.1186/1744-9081-4-52
Received: 1 June 2008 Accepted: 18 November 2008
This article is available from: http://www.behavioralandbrainfunctions.com/content/4/1/52 © 2008 Virit et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Alterations in ceruloplasmin are currently assumed as one of the mechanisms underlying the development of a number of neurodegenerative disorders. Several studies indicate that elevated serum ceruloplasmin levels may play a role in schizophrenia by exacerbating or perpetuating dopaminergic dysregulation. No study investigating the relationship between ceruloplasmin and obsessive-compulsive disorder (OCD) has been published to date. Nowadays OCD is increasingly speculated to be a different disorder than other anxiety disorders, and rather is considered to be more similar to psychotic disorders. The objective of this study to explore whether there is an association of ceruloplasmin with OCD as in schizophrenia. Method: 26 pure OCD and 9 co-morbid OCD patients from Gaziantep University Sahinbey Research Hospital, Psychiatry Clinics, diagnosed according to the DSM IV and 40 healthy controls were included in the study. Blood samples were collected; ceruloplasmin levels were measured. Results: The mean ceruloplasmin level in pure OCD patients, co-morbid OCD patients, and control group persons were 544.46 ± 26.53, 424.43 ± 31.50 and 222.35 ± 8.88 U/L respectively. Results of all 3 groups differ significantly. Positive predictive value of ceruloplasmin for that cut-off point is 31/31 (100%) and negative predictive value is 40/44 (91%) in our group. Conclusion: Although the nature of relationship is not clear there was an association between ceruloplasmin levels and OCD in our study.
Background
Ceruloplasmin is a protein of the α2-globulin fraction of human blood serum.
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