High Density Lipoproteins, Dyslipidemia, and Coronary Heart Disease
This innovative book focuses on HDL and its relationships to triglyceride-rich particles. As new therapies for HDL raising become available, a comprehensive understanding the role of HDL in Coronary Heart Disease is of great importance. This book is an ex
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Ernst J. Schaefer Editor
High Density Lipoproteins, Dyslipidemia, and Coronary Heart Disease
Editor Ernst J. Schaefer, MD Tufts University School of Medicine Boston, MA USA [email protected]
ISBN 978-1-4419-1058-5 e-ISBN 978-1-4419-1059-2 DOI 10.1007/978-1-4419-1059-2 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2009943544 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or ommissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
In this book and atlas entitled High Density Lipoproteins, Dyslipidemia, and Coronary Heart Disease, I am indebted to the many chapter authors who have contributed their writing as well as their insights. The work grew out of a meeting on high density lipoproteins (HDLs), chaired by me and Dr. Vassilis Zannis of Boston University, and held on June 19 and 20, 2009 in Newport, Rhode Island, as a satellite meeting following the 15th International Symposium on Atherosclerosis, held in Boston. In the introduction our understanding of overall lipoprotein metabolism is reviewed, as well as the common genetic lipoprotein disorders associated with premature coronary heart disease (CHD). These familial disorders include lipoprotein(a) excess, dyslipidemia (high triglycerides and low HDL), combined hyperlipidemia (high cholesterol and high triglycerides often with low HDL), hypoalphalipoproteinemia (low HDL), and hypercholesterolemia. We discuss the management of these disorders. We also review other disorders including cerebrotendinous xanthomatosis, phytosterolemia, deficiency of apolipoprotein B, and severe hypertriglyceridemia. The latter disorder can be associated with pancreatitus. Thereafter, the focus is on HDL, beginning with chapters on the regulation of apolipoprotein (apo) A-I gene expression, the composition, remodeling, and the metabolism of HDL particles, as well as HDL structure, function, and its anti-inflammatory properties. Then th
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