High NEMO score values in nailfold videocapillaroscopy are associated with the subsequent development of ischaemic digit
- PDF / 667,344 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 57 Downloads / 172 Views
(2020) 22:237
RESEARCH ARTICLE
Open Access
High NEMO score values in nailfold videocapillaroscopy are associated with the subsequent development of ischaemic digital ulcers in patients with systemic sclerosis Nicoletta Del Papa1*, Francesca Pignataro1, Wanda Maglione1, Antonina Minniti1, Domenico Sambataro2, Gianluca Sambataro3, Gabriele Valentini4, Roberto Caporali5 and Claudio Vitali6
Abstract Background: Nailfold videocapillaroscopy (NVC) is a feasible method that allows the observation of the microvascular changes that mark the course of systemic sclerosis (SSc). In previous studies, we demonstrated that the NEMO score, i.e. the cumulative number of microhaemorrhages and microthromboses, is a good indicator of the steady-state level and overtime changes of disease activity (DA) in SSc. Objectives: To verify whether high NEMO scores, which mirror a very active microvascular derangement in the fingers, may be associated with the subsequent development of ischaemic digital ulcers (IDUs). Methods: The NEMO score was assessed at baseline (T0) in 98 patients with SSc, all classified according to the ACREULAR criteria. Of them, 90 were females, 48 had the limited and 50 had the diffuse cutaneous variant of SSc. Afterwards, the patients were closely followed up for 2 years, and the appearance of new IDUs recorded at any time of the follow-up. The T0-NEMO score values of patients who developed IDUs were compared to those of patients who did not. A receiver operating curve (ROC) was constructed, and the area under the curve (AUC) calculated by plotting the sensitivity and 1-specificity of the different NEMO score values in predicting the subsequent development of IDUs. (Continued on next page)
* Correspondence: [email protected] 1 Department of Rheumatology, UOC Day Hospital of Rheumatology, ASST G.Pini-CTO, 20122 Milan, Italy Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Del Papa et al. Arthritis Research & T
Data Loading...
