High platelet count is associated with low bone mineral density: The MrOS Sweden cohort
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ORIGINAL ARTICLE
High platelet count is associated with low bone mineral density: The MrOS Sweden cohort H.L. Kristjansdottir 1 & D. Mellström 2,3 & P. Johansson 1 & M. Karlsson 4 & L. Vandenput 2,5 & M. Lorentzon 2,3,5 & H. Herlitz 6 & C. Ohlsson 2,7 & U.H. Lerner 2 & C. Lewerin 1 Received: 3 September 2020 / Accepted: 25 November 2020 # The Author(s) 2020
Abstract Summary In elderly ambulatory men, high platelet and high neutrophil counts are related to low bone mineral density (BMD), after adjustment for relevant covariates. Low hemoglobin (hgb) is even associated with low BMD, but this relationship seems to be dependent on estradiol and osteocalcin. Purpose Blood and bone cells exist in close proximity to each other in the bone marrow. Accumulating evidence, from both preclinical and clinical studies, indicates that these cell types are interconnected. Our hypothesis was that BMD measurements are associated with blood count variables and bone remodeling markers. Methods We analyzed blood count variables, bone remodeling markers, and BMD, in subjects from the MrOS cohort from Gothenburg, Sweden. Men with at least one blood count variable (hgb, white blood cell count, or platelet count) analyzed were included in the current analysis (n = 1005), median age 75.3 years (range 69–81 years). Results Our results show that high platelet counts were related to low BMD at all sites (total hip BMD; r = − 0.11, P = 0.003). No statistically significant association was seen between platelet counts and bone remodeling markers. Neutrophil counts were negatively associated with total body BMD (r = − 0.09, P = 0.006) and total hip BMD (r = − 0.08, P = 0.010), and positively related to serum ALP (r = 0.15, P < 0.001). Hgb was positively related to total hip BMD (r = 0.16, P < 0.001), and negatively to
* H.L. Kristjansdottir [email protected]
1
Section of Hematology and Coagulation at the Sahlgrenska University Hospital and Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Bruna Stråket 5, 413 45 Gothenburg, Sweden
2
Center for Bone and Arthritis Research (CBAR) at the Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
3
Department of Geriatric Medicine, Internal Medicine, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
4
H. Herlitz [email protected]
Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences and Orthopedics, Skåne University Hospital (SUS), Lund University, Malmö, Sweden
5
C. Ohlsson [email protected]
Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia
6
Department of Molecular and Clinical Medicine/Nephrology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
7
Department of Drug Treatment, Sahlgrenska University Hosp
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