High Resolution FISH of Stretched Chromosome Fibers
High resolution fluorescence in situ hybridization (FISH), so-called FIBER-FISH, was first described by Heng et al. (1992) for long stretched DNA-fibers and was later subjected to modifications by other investigators (Fidlerova et al. 1994, Heiskanen et a
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Springer-Verlag Berlin Heidelberg GmbH
Bernd W. Rautenstrauß
Thomas Liehr (Eds.)
FISH Technology
With 78 Figures, 44 in colour
Springer
BERND W. RAUTENSTRAUSS
Institut für Humangenetik Universität Erlangen-Nürnberg Schwabachanlage 10 91054 Erlangen Germany e-mail: [email protected]
T H O M A S LIEHR
Institut für Humangenetik Universität Jena Kollegiengasse 10 077743 Jena Germany e-mail: [email protected]
Library of Congress Cataloging-in-Publication Data FISH technology / Bernd W. Rautenstrauss, Thomas Liehr (eds.) p. cm. - (Springer lab manuals) Includes bibliographical references. ISBN 978-3-642-56404-8 (eBook) ISBN 978-3-642-47739-3 DOI 10.1007/978-3-642-56404-8 I. Fluorescence in situ hybridization ~ Laboratory manuals. I. Rautenstrauss, Bernd W., 1959 II. Liehr, Thomas, 1965- III. Springer lab manual. QP519.9.F56.F574 2002 572.8*028*4-0021 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9,1965, in its current version, and permissions for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law.
© Springer-Verlag Berlin Heidelberg 2002 Originally published by Springer-Verlag Berlin Heidelberg New York in 2002 Softcover reprint of the hardcover 1 st edition 2002 http://www.springer.de The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher cannot guarantee the accuracy of any information about dosage and application thereof contained in this book. In every individual case the user must check such information by consulting the relevant literature. Production: PRO EDIT GmbH, 69126 Heidelberg, Germany Cover design: design & production GmbH, 69121 Heidelberg, Germany Typesetting: Mitterweger + Partner, 68723 Plankstadt, Germany SPIN 10674102 39/3130S0 5 4 3 2 1 0 - Printed on acid free paper
Preface
The fluorescence in situ hybridization (FISH) technique has nowadays become a powerful and versatile tool in clinical genetics, tumor cytogenetics and science. Invented in the 1970's there were many problems to overcome in working out the methodology. However, the technique is now established in many cytogenetic and other clinically orientated routine laboratories as well as in many research facilities allover the world. This book is part of a series oflabmanuals providing practical aspects of technologies used in biology, medicine and genetics. As in many cases published methods are incomplete or refer back to s
