High throughput fabrication of curcumin embedded gelatin-polylactic acid forcespun fiber-aligned scaffolds for the contr
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Research Letter
High throughput fabrication of curcumin embedded gelatin-polylactic acid forcespun fiber-aligned scaffolds for the controlled release of curcumin Narsimha Mamidi, Tecnológico de Monterrey, Campus Monterrey, School of Engineering and Science, Eugenio Garza Sada 2501 Sur, Col Tecnológico C.P. 64849, Monterrey, Nuevo León, México Irasema Lopez Romo, Tecnológico de Monterrey, Centro de Biotecnología-FEMSA, School of Engineering and Science, Av. Eugenio Garza Sada 2501, Monterrey, N.L., C.P. 64849, México Enrique V. Barrera, Tecnológico de Monterrey, Campus Monterrey, School of Engineering and Science, Eugenio Garza Sada 2501 Sur, Col Tecnológico C.P. 64849, Monterrey, Nuevo León, México; Department of Materials Science and NanoEngineering, Rice University, Houston, TX 77005, USA; Department of Chemistry, Rice University, Houston, TX 77005, USA Alex Elías-Zúñiga, Tecnológico de Monterrey, Campus Monterrey, School of Engineering and Science, Eugenio Garza Sada 2501 Sur, Col Tecnológico C.P. 64849, Monterrey, Nuevo León, México Address all correspondence to N. Mamidi at [email protected] (Received 29 May 2018; accepted 31 August 2018)
Abstract The aim of current study is to fabricate implantable curcumin embedded gelatin/polylactic acid/curcumin (GL/PLA/Cur) aligned fiber scaffolds by forcespinning®, which might have a potential application in drug delivery and cancer therapy. Fourier Transform Infrared Spectroscopy reveals the hydrogen bonding interactions between GL, PLA, and curcumin. In vitro curcumin drug release from GL/PLA/Cur fiber scaffolds is investigated and sustained release is observed over 15 days. Further, cell viability assay reveals that GL/PLA/Cur aligned fibers show excellent growth of human fibroblast cells. These results strongly suggest that the curcumin bearing GL/PLA/Cur composite fibers may show the potential application in cancer therapy, drug delivery, and wound dressing.
Introduction Since ancient times, several herbal biomaterials play a vital role in the wound healing applications. Curcumin (diferuloylmethane) is a biocompatible and biodegradable yelloworange phenolic compound, extracted from the rhizomes of Curcuma longa (turmeric).[1] Typically used in Asian foods as spice ingredient, specifically in India and Eastern Asia.[2] Curcumin exhibits numerous therapeutic properties including anti-inflammatory, antifungal, antioxidant, antiviral, antibacterial, and anticancer.[1–3] Further, it showed a potential to treat asthma, diabetes, allergies, arthritis, neurodegeneration disease, atherosclerosis, and chronic cancer.[4–10] Several clinical trials for human cancer have demonstrated the effectiveness, pharmacokinetics, and safety of curcumin.[1,2] However, clinical effect and bioavailability of curcumin are greatly limited due to its hydrophobic nature. Therefore, it is important to improve the solubility of curcumin by functionalization or select the appropriate method to deliver the drug in a specific tumor site.[11] Usually, nanoparticles, cast films, hydrogels, and ultrafine nanofiber
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