How Ricin Reaches its Target in the Cytosol of Mammalian Cells
The cytotoxic plant protein ricin comprises a lectin B chain that binds promiscuously to glycolipids and glycoproteins at the surface of mammalian cells, disulphide-coupled to a toxic A chain which depurinates target ribosomes. To find these cytosolic tar
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Series Editor: David G. Robinson Heidelberg, Germany
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J. Michael Lord
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Martin R. Hartley
Editors
Toxic Plant Proteins
Editors Dr. J. Michael Lord University of Warwick Dept. Biological Sciences CV4 7AL Coventry United Kingdom [email protected]
Dr. Martin R. Hartley University of Warwick Dept. Biological Sciences CV4 7AL Coventry United Kingdom [email protected]
Series Editor Professor Dr. David G. Robinson Ruprecht-Karls-University of Heidelberg Heidelberger Institute for Plant Sciences (HIP) Department Cell Biology Im Neuenheimer Feld 230 69120 Heidelberg Germany
ISSN 1861-1370 e-ISSN 1861-1362 ISBN 978-3-642-12175-3 e-ISBN 978-3-642-12176-0 DOI 10.1007/978-3-642-12176-0 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2010929802 # Springer-Verlag Berlin Heidelberg 2010 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in
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