Human Glioblastoma Organoids to Model Brain Tumor Heterogeneity Ex Vivo
Intratumoral cellular heterogeneity is a clinically important aspect of most cancers. Diffusion limitations in solid tumors create oxygen and nutrient gradients that support different cellular phenotypes within distinct tumor regions. Until recently, meth
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Giorgio Seano Editor
Brain Tumors
Neuromethods
Series Editor Wolfgang Walz University of Saskatchewan Saskatoon, SK, Canada
For further volumes: http://www.springer.com/series/7657
Neuromethods publishes cutting-edge methods and protocols in all areas of neuroscience as well as translational neurological and mental research. Each volume in the series offers tested laboratory protocols, step-by-step methods for reproducible lab experiments and addresses methodological controversies and pitfalls in order to aid neuroscientists in experimentation. Neuromethods focuses on traditional and emerging topics with wide- ranging implications to brain function, such as electrophysiology, neuroimaging, behavioral analysis, genomics, neurodegeneration, translational research and clinical trials. Neuromethods provides investigators and trainees with highly useful compendiums of key strategies and approaches for successful research in animal and human brain function including translational “bench to bedside” approaches to mental and neurological diseases.
Brain Tumors Edited by
Giorgio Seano INSERM U1021 - CNRS UMR3347, Institut Curie Research Center, Paris-Orsay, France
Editor Giorgio Seano INSERM U1021 - CNRS UMR3347 Institut Curie Research Center Orsay, France
ISSN 0893-2336 ISSN 1940-6045 (electronic) Neuromethods ISBN 978-1-0716-0855-5 ISBN 978-1-0716-0856-2 (eBook) https://doi.org/10.1007/978-1-0716-0856-2 © Springer Science+Business Media, LLC, part of Springer Nature 2021 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Cover Caption: High-resolution 3D intravital imaging of brain vasculature. Dextran perfused vasculature of the brain cortex imaged thought chronic cranial window (see Chapter 4 for technical details). Cover by Dr. Seano Giorgio. This Springer imprint is published by the registered company Springer Science+Business Media, LLC part
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