Humanized Mice
The term humanized mouse in this text refers to a mouse in which human tissues and cells have been transplanted and show the same biological function as they do in the human body. That is, the physiological properties and functions of tra- planted human t
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Tatsuji TatsujiNomura Nomura Takeshi TakeshiWatanabe Watanabe Sonoko SonokoHabu Habu Editors Editors
Humanized Humanized Mice Mice
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Current Topics in Microbiology and Immunology Volume 324
Series Editors Richard W. Compans Emory University School of Medicine, Department of Microbiology and Immunology, 3001 Rollins Research Center, Atlanta, GA 30322, USA Max D. Cooper Howard Hughes Medical Institute, 378 Wallace Tumor Institute, 1824 Sixth Avenue South, Birmingham, AL 35294-3300, USA Tasuku Honjo Department of Medical Chemistry, Kyoto University, Faculty of Medicine, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan Hilary Koprowski Thomas Jefferson University, Department of Cancer Biology, Biotechnology Foundation Laboratories, 1020 Locust Street, Suite M85 JAH, Philadelphia, PA 19107-6799, USA Fritz Melchers Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstr. 50–70, 4056 Basel Switzerland Michael B.A. Oldstone Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, 10550 N. Torrey Pines, La Jolla, CA 92037, USA Sjur Olsnes Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello 0310 Oslo, Norway Peter K. Vogt The Scripps Research Institute, Dept. of Molecular & Exp. Medicine, Division of Oncovirology, 10550 N. Torrey Pines. BCC-239, La Jolla, CA 92037, USA
Tatsuji Nomura • Takeshi Watanabe Sonoko Habu Editors
Humanized Mice
Tatsuji Nomura, M.D., Ph.D. Central Institute for Experimental Animals, Kawasaki, Japan [email protected]
Takeshi Watanabe, M.D., Ph.D. RIKEN, Yokohama, Japan [email protected]
Sonoko Habu, M.D., Ph.D. Tokai University School of Medicine, Kanagawa, Japan [email protected]
ISBN 978-3-540-75646-0 e-ISBN 978-3-540-75647-7 DOI 10.1007/978-3-540-75647-7 Current Topics in Microbiology and Immunology ISSN 007-0217x Library of Congress Catalog Number: 72-152360 © 2008 Springer-Verlag Berlin Heidelberg This work is subject to copyright. All rights reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September, 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cov
