Humoral Regulation of Eosinophil Granulocytopoiesis

Studies on the humoral regulation of granulocytopoiesis have, for several reasons, met with frustration since the beginning of experimentation on this problem. Stimulators for the initiation of granulocytosis are ubiquitious, resulting in uncontrolled and

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edited by SIEGMUND J. BAUM G. DAVID LEDNEY

EXPERIMENTAL HEMATOLOGY TODAY With 147 Illustrations

SPRINGER SCIENCE+BUSINESS MEDIA, LLC

Siegmund J. Baum Chairman, Experimental Hematology Department Armed Forces Radiobiology Research Institute Defense Nuclear Agency Bethesda, Maryland 20014 G. David Ledney Head, Immunology Division Experimental Hematology Department Armed Forces Radiobiology Research Institute Defense Nuclear Agency Bethesda, Maryland 20014 This book contains selected papers presented at the Egon Lorenz Memorial Symposia, Fifth Annual Meeting, International Society for Experimental Hematology, August 17-20, 1976, Washington, D.C., U.S.A. Designer: Robert Bull

Library of Congress Cataloging in Publication Data Egon Lorenz Memorial Symposia, Washington, D.C., 1976. Experimental hematology today. Bibliography: p. Includes index. I. Hematology-Congresses. I. Baum, Siegmund J. II. Ledney, G. David. III. International Society for Experimental Hematology. IV. Title. [DNLM: I. Hematology-Congresses. WHIOO E96 1976] 77-8668 612.11 QP91.E35 1976

All rights reserved. No part of this book may be translated or reproduced in any form without written permission from Springer Science+Business Media, LLC.

© 1977 by Springer Science+Business Media New York Originally published by Springer-Verlag New York, Inc. in 1977 Softcover reprint of the hardcover 1st edition 1977

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ISBN 978-3-662-25807-1 (eBook) ISBN 978-3-540-90208-9 DOI 10.1007/978-3-662-25807-1

Experimental Hematology Today is divided into six sections which are related to the presentations given at the Egan Lorenz Memorial Symposia presented as part of the Fifth Annual Meeting of the International Society for Experimental Hematology held in Washington, D.C. in 1976. The first division deals with papers from Symposium I chaired by Dr. Dirk W. van Bekkum, Rijswijk, Netherlands. Its topic is "Characterization of the Multipotential Stem Cell (CFU-s)," and represents a report of the most recent attempts of separation and description of the multipotential hematopoietic stem cell. The papers presented in Symposium II entitled "Humoral and Cellular Control Agents" and chaired by Dr. Eugene P. Cronkite, Brookhaven, New York, discuss the latest findings of the influence of specific factors on hematopoietic cell production. The third division is comprised of presentations from Symposium III entitled "Physiology of Committed Stem Cells (CFU-e and CFU-m)." It was chaired by Dr. James E. Till, Toronto, Canada. The papers of this symposium discuss the function of the erythrocytic and megakaryocytic committed stem cells. The papers from Symposium IV entitled "Physiology of Committed Stem Cells (CFU-c)," chaired by Dr. Siegmund J. Baum, Bethesda, Maryland, are presented in the fourth division. This division deals with the latest research findings of the functional interrelationship of the leukocytic committed stem cells. The topic of Symposium V was "Bone Marrow Transplantation Immunology" chaired by Dr. John J. Trentin, Houston, Texas. The papers o