Hybrid Artificial Liver

Hybrid artificial liver (HAL) is the combination of the biological artificial liver (BAL) and the non-biological artificial liver (N-BAL) support systems together in an extracorporeal circulation, which can replace the liver in terms of detoxification, sy

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Artificial Liver

Lanjuan Li Editor

Artificial Liver

Editor Lanjuan Li The First Affiliated Hospital Zhejiang University Zhejiang University Hangzhou China

ISBN 978-981-15-5983-9    ISBN 978-981-15-5984-6 (eBook) https://doi.org/10.1007/978-981-15-5984-6 © Springer Nature Singapore Pte Ltd. and Zhejiang University Press 2021 Jointly published with Zhejiang University Press This work is subject to copyright. All rights are reserved by the Publishers, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publishers, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publishers nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publishers remain neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore

Preface

Liver failure is a critical illness with a high mortality rate, which is a worldwide problem for treatment. An artificial liver is a sort of effective and practical method for the clinical treatment of liver failure, and it can remove various harmful substances and compensate for liver functions in order to improve the internal environment and facilitate cellular regeneration, thus rescuing the patients with liver failure from death. Furthermore, it can also be utilized as a “bridge” before transplant to extend the waiting time for a donor liver for patients with advanced liver failure, improving preoperative conditions and the success rate of liver transplant. In order to popularize the concept of and the treatment technology for artificial livers, we have compiled and published the first monograph, named Artificial Liver, in 2001 in China, which systematically introduced the history and mechanism of artificial livers, non-bioartificial and bioartificial livers, hybrid artificial livers, the prevention and treatment of complications, as well as severe hepatitis, liver failure, and artificial livers in liver transplants. The publication of Artificial Liver has strongly promoted the popularization and generalization of art