Hybrid Imaging for Male Malignancies
Prostate carcinoma is the most common life-threatening cancer affecting men in the Western world. Rates of detection vary, with a lower prevalence in South and East Asia than in Europe and the United States [1]. Prostate carcinoma is more common in men ov
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Akram Al-Ibraheem, Abdullah S. Al Zreiqat, Serena Chiacchio, and Abedallatif A. AlSharif
Contents 35.1 Prostate Cancer 35.1.1 Clinical Background 35.1.2 Conventional Bone Scintigraphy 35.1.3 18F-Fluoride PET/CT 35.1.4 [18F]FDG PET/CT 35.1.5 [11C]Choline and 18F-Choline PET/CT 35.1.6 68Ga-PSMA-Ligand PET/CT 35.1.7 Perspectives for 18F-FACBC PET/CT
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35.2 Testicular Cancer 35.2.1 Clinical Background 35.2.2 [18F]FDG PET/CT in Testicular Cancer
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35.3 Penile Cancer 35.3.1 Clinical Background 35.3.2 Bone Scintigraphy 35.3.3 Sentinel Lymph Node Biopsy 35.3.4 PET/CT with [18F]FDG
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References
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Learning Objectives
• Summarize the main features regarding epidemiology, etiology, histopathology, and most common clinical presentation of male malignancies, including prostate cancer, testicular cancer, and penile cancer.
A. Al-Ibraheem Department of Nuclear Medicine, King Hussein Cancer Center, Amman, Jordan A. S. Al Zreiqat Department of Nuclear Medicine, Jordanian Royal Medical Services, Amman, Jordan S. Chiacchio Regional Center of Nuclear Medicine, University Hospital of Pisa, Pisa, Italy A. A. AlSharif (*) Department of Radiology and Nuclear Medicine, School of Medicine, Jordan University Hospital, University of Jordan, Amman, Jordan e-mail: [email protected]
• Understand the pathophysiologic basis and the clinical rationale for the residual use of bone scintigraphy with 99m Tc-bisphosphonates in patients with prostate cancer. • Summarize the basic modalities for performing and interpreting bone scintigraphy with 99mTc-bisphosphonates, including planar imaging and SPECT/CT imaging. • Understand the pathophysiologic basis and the clinical rationale for the emerging use of PET/CT with 18F-NaF for detecting skeletal metastasis in patients with prostate cancer. • Summarize the basic modalities of performing and interpreting a PET/CT scan with 18F-NaF PET/CT in patients with prostate cancer. • Understand the pathophysiologic basis for the use of PET/CT imaging with [18F]FDG in patients with prostate cancer. • Summarize the basic modalities of performing and interpreting a PET/CT scan with [18F]FDG PET/CT in patients with prostate cancer.
© Springer Nature Switzerland AG 2019 D. Volterrani et al. (eds.), Nuclear Medicine Textbook, https://doi.org/10.1007/978-3-319-95564-3_35
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• Understand the pathophysiologic basis and the clinical rationale for the use of PET/CT with [11C]choline or 18 F-choline in patients with prostate cancer. • Summarize the basic modalities of performing and interpreting a PET/CT scan with [11C]choline or 18F-choline in patients with prostate cancer. • Understand the pathophysiologic basis and the clinical rationale for the use of PET/CT with 68Ga-PSMA-ligand in patients with prostate cancer. • Summarize the basic modalities of performing and interpreting a PET/CT scan with 68Ga-PSMA-ligand in patients with prostate cancer. • Summari
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