Hydrolytic Degradation of PPDO/PDLLA Blends Containing the Compatibilizer PLADO
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ORIGINAL PAPER
Hydrolytic Degradation of PPDO/PDLLA Blends Containing the Compatibilizer PLADO Yang Bai • Pingya Luo • Pingquan Wang • Wei Bai • Chengdong Xiong • Congming Tang
Ó Springer Science+Business Media New York 2013
Abstract The poly(para-dioxanone) (PPDO)/poly poly (DL-lactide) (PDLLA) blends containing various contents of compatibilizer (0, 1, 3, 5, 10 %) were prepared by solution co-precipitation, which were dissolved in 1,1,1,3, 3,3-hexafluoro-2-propanol (HFIP) to form 10 % wt/vol solutions. Then in vitro hydrolytic degradation of PPDO/ PDLLA blends containing poly (DL-lactide-co-para-dioxanone) (PLADO) as the compatibilizer was studied by the changes of weight loss, water absorption, thermal properties, surface morphology and mechanical properties of samples in phosphate buffered saline (pH 7.44) at 37 °C for 8 weeks. During the degradation, the weight loss and water absorption increased significantly for all blends, whereas hydrolysis rate of blends varied with the blend composition. The samples’ glass transition temperature decreased notably, while the degrees of crystallinity increased. Compared with uncompatibilized PPDO/PDLLA blends, PPDO/PDLLA blends with compatibilizer exhibited higher hydrolysis rate. The results suggested that the compatibilizer (PLADO) accelerated the hydrolysis rate of PPDO/PDLLA blends during the degradation.
Y. Bai P. Luo P. Wang W. Bai (&) State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation, Southwest Petroleum University, Chengdu 610500, People’s Republic of China e-mail: [email protected] W. Bai C. Xiong Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, People’s Republic of China W. Bai C. Tang Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637009, People’s Republic of China
Keywords Biomaterials Compatibilizer PPDO/ PDLLA Blends In vitro hydrolytic degradation
Introduction Poly (para-dioxanone) (PPDO) is a biodegradable polymer material which is of high significance in a wide range of biomedical applications [1–4]. It is extensively used as a bonerepair device, bone-substitute material and other biomaterials [5–7]. However, its high cost and relatively low crystallization rate among other factors has hindered its development in commercial applications [8]. To overcome these disadvantages, copolymer synthesis, polymer blending and composites methods have been developed. Owing to simple and lower cost, blending with other polymers is a convenient way of modifying the properties of PPDO. According to this, we have prepared PPDO/poly poly (DL-lactide) (PDLLA) blends possessing a wide variety of mechanical and thermal properties [9]. Furthermore, poly (DL-lactide-co-para-dioxanone) (PLADO) as the compatibilizer was added to the blends [10], to enhance the compatibility between dispersed particles PDLLA and PPDO matrix to achieve better results. In our earlier work, we have reported th
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