Hypoparathyroidism
Hypoparathyroidism, a condition in which insufficient parathyroid hormone (PTH) is produced to maintain normocalcemia is associated with a variety of acute and chronic symptoms and complications due to hypocalcemia. Replacement therapy utilizing PTH has l
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Hypoparathyroidism
Maria Luisa Brandi Edward Meigs Brown Editors
Hypoparathyroidism
Editors Maria Luisa Brandi, MD, PhD Unit of Metabolic and Bone Diseases University of Florence Florence Italy
Edward Meigs Brown, MD Division of Endocrinology, Diabetes and Hypertension Harvard Medical School and Brigham and Women’s Hospital Boston, MA USA
ISBN 978-88-470-5375-5 ISBN 978-88-470-5376-2 DOI 10.1007/978-88-470-5376-2 Springer Milan Heidelberg New York Dordrecht London
(eBook)
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Foreword
Hypoparathyroidism, manifesting as tetany, was first encountered in the late nineteenth century as a postoperative complication of total thyroidectomy, but, as described by Mannstadt and Potts in the first chapter of this volume, the connection between parathyroid glands, post-thyroidectomy tetany, and hypocalcemia took years to be elucidated. Isolation and characterization, first from bovine and then from human parathyroid glands, of the biologically relevant agent parathyroid hormone (PTH) took decades more. The pioneering work of the late Gerald Aurbach in this endeavor (as cited by Mannstadt and Potts) and in many other seminal studies that
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