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Diarrhoea and Fanconi syndrome: 2 case reports A case series of 7 patients with Ewing sarcoma family of tumours (ESFT), two patients were described, of whom an adolescent boy [exact age not stated] developed diarrhoea during treatment with irinotecan, and a 15-year-old girl developed Fanconi syndrome during treatment with ifosfamide for metastatic ESFT [routes, dosages, duration of treatments to reactions onsets and outcomes not stated]. The boy presented at the age of 11 years with several weeks of the testicle and left flank pain, along with several days of fever. Upon evaluation, remarkable osseous pelvic metastatic disease was observed. Hence, a left nephrectomy was performed, and subsequent pathology showed an EWSR1 rearrangement, which indicated metastatic ESFT. Subsequently, he received VDC-IE chemotherapy, which included vincristine, doxorubicin, cyclophosphamide and ifosfamide. After induction and two cycles of consolidation therapy, he received conditioning with melphalan, busulfan and thiotepa, followed by autologous stem cell rescue. Subsequently, treatment with everolimus as maintenance chemotherapy was given for a year. Approximately, 5 years after stem cell rescue (4 years after everolimus therapy), he re-presented with abdominal pain, which was initially considered as appendicitis. However, upon evaluation, disease recurrence with previous noted EWSR1 rearrangement was observed. Also, the chest CT scan showed multiple bilateral pulmonary nodules. Hence, he started receiving treatment with a VIT regimen, which included vincristine, irinotecan and temozolomide. He had received 6 cycles of treatment. However, he developed severe irinotecan-induced diarrhoea. Hence, treatment with VIT was switched to vincristine, topotecan and cyclophosphamide (VTC) for 2 cycles alternating with VIT. Five months after disease relapse (5.5 years after diagnosis), he was alive with disease. A 15-year-old girl presented with ataxia, back pain and left abdominal pain. Imaging studies showed complete occlusion of the inferior vena cava (IVC), large left renal mass and bilateral pulmonary metastasis. Hence, she underwent IVC thrombectomy, left nephrectomy and partial ureterectomy. Intraoperatively, she had a tumour spill. The FISH analysis revealed EWSR1 gene rearrangement with bone marrow involvement, which indicated metastatic ESFT. Postoperatively, she received one cycle of VDC/IE regimen, which included vincristine, doxorubicin, cyclophosphamide and ifosfamide. However, after the administration of ifosfamide, she developed Fanconi syndrome associated with ifosfamide. Hence, her subsequent cycles were switched with cyclophosphamide. She had a partial response with induction therapy. Afterwards, consolidation therapy with vincristine, doxorubicin, cyclophosphamide/cyclophosphamide (VDC/CE) and pulmonary radiation was initiated. Six months after completion of therapy, she had a relapse with liver and lung metastasis. She had received two cycles of unspecified chemotherapy and one cycle of salvage therapy for persistent