IGFs:Local Repair and Survival Factors Throughout Life Span
Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 i
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David Clemmons Yves Christen
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Iain C.A.F. Robinson
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Editors
IGFs: Local Repair and Survival Factors Throughout Life Span
Editors Dr. David Clemmons University of North Carolina School of Medicine Div. of Endocrinology 8024 Burnett-Womack Hall Chapel Hill NC 27599-7170 USA [email protected]
Dr. Iain C.A.F. Robinson National Inst. Med. Research Lab. Endocrine Physiology The Ridgeway London Mill Hill United Kingdom NW7 1AA [email protected]
Dr. Yves Christen Fondation IPSEN pour la Recherche Therapeutique 65 quai George Gorse 92650 Boulogne Billancourt Cedex France [email protected]
ISSN: 1861-2253 ISBN: 978-3-642-04301-7 e-ISBN: 978-3-642-04302-4 DOI 10.1007/978-3-642-04302-4 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2009935699 # Springer-Verlag Berlin Heidelberg 2010 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Cover design: WMXDesign GmbH, Heidelberg, Germany Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Foreword
Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.
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