Image Fusion in Preclinical Applications
This book provides an accessible and comprehensive overview of the state of the art in multimodal, multiparametric preclinical imaging, covering all the modalities used in preclinical research. The role of different combinations of PET, CT, MR, optical, a
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Image Fusion in Preclinical Applications
Claudia Kuntner-Hannes • York Haemisch Editors
Image Fusion in Preclinical Applications
Editors Claudia Kuntner-Hannes Center for Health & Bioresources AIT Austrian Institute of Technology GmbH Seibersdorf Austria
York Haemisch Technical Sales & Business Development Direct Conversion GmbH München Germany
ISBN 978-3-030-02972-2 ISBN 978-3-030-02973-9 (eBook) https://doi.org/10.1007/978-3-030-02973-9 Library of Congress Control Number: 2018964720 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
In the last decade, our understanding of the function of the human body and the interaction of drugs with certain molecular targets has increased significantly. This deepened insight is a result of the wider availability of new diagnostic tools such as those developed by the different “-omics” disciplines (genomics, proteomics, etc.), but largely also of the application of noninvasive, in vivo imaging techniques applying molecular targets and markers. In vivo imaging modalities have different characteristics based on their individual mechanisms of tissue contrast or function, specific sensitivity, and spatial and temporal resolution in relationship to diseases or biological processes. Multimodality imaging using two or more imaging modalities simultaneously or sequentially allows the combination of the strengths of individual modalities while overcoming their limitations. Anatomical imaging techniques such as (X-ray) computed tomography (CT) and functional imaging such as magnetic resonance imaging (MRI) provide excellent structural detail and resolution. Molecular imaging techniques such as positron e
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