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Hypoalbuminaemia and generalised oedema: case report In a single-blind, case-control study conducted (between 01 January 2018 and 30 June 2018) in the NICU of the Sir Takhtasinhji General Hospital, India, a neonate [sex and exact age not stated] was described, who developed hypoalbuminaemia and generalised oedema during treatment with immune globulin for bacterial sepsis. The very low birth weight neonate was admitted due to probable bacterial sepsis and received treatment with ampicillin, cefotaxime and other unspecified antibiotic. After 72h, blood culture reports were positive. From admission day 3, the neonate started receiving treatment with IV infusion of IgM-rich immune globulin at a dose of 5 mL/kg/day over 3 hours for five consecutive days. The neonate also received concomitant unspecified antibacterials [antibiotics]. Within one week of completion of immune globulin treatment, the neonate started developing generalised oedema. The neonate also gained weight of 100g in 24h. Hypoalbuminaemia (serum albumin level: 2.7 g/dL) was noted, which was thought to be related to immune globulin. The neonate was treated with albumin human [human albumin]. After single administration of albumin human, oedema started resolving. The neonate was discharged. Jindal SV, et al. Efficacy of igm-rich immunoglobin for treating bacterial sepsis in very-low-birth-weight preterm neonates. Perinatology 20: 114-119, No. 4, Jan-Mar 2020. Available from: URL: https://static1.squarespace.com/static/59f2d244cf81e03e96b107ea/t/5e5c973a483fcf203373c429/1583126333285/ 803507080 Efficacy+of+IgM+Rich+Immunoglobin+for+Bacterial+Sepsis.pdf

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Reactions 17 Oct 2020 No. 1826