Impact of Androgen Receptor Gene Expression in Gastric Cancer: a Meta-Analysis Based on the GEO Database, TCGA Database,
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ORIGINAL ARTICLE
Impact of Androgen Receptor Gene Expression in Gastric Cancer: a Meta-Analysis Based on the GEO Database, TCGA Database, and Literature Huafu Li 1,2 & Zhewei Wei 2 & Chunming Wang 1,2 & Wei Chen 2 & Yulong He 1,2 & Changhua Zhang 1,2 Received: 14 June 2019 / Accepted: 26 March 2020 # Association of Surgeons of India 2020
Abstract To evaluate androgen receptor and AR gene expression impact of gastric cancer (GC). Meta-analysis of microarray data obtained from the Gene Expression Omnibus (GEO) database, TCGA (The Cancer Genome Atlas) database, and data by systematic search of PubMed, China National Knowledge Internet and Web of Science. This meta-analysis included 30 studies involving 4487 patients. From our results, we can know that the positive rate of AR expression in gastric cancer is 40%. The expression of AR was significantly higher in men (SWD = 1.00, 95% CI 0.03 ~ 1.96, P = 0.042). The higher AR expression was linked with poor over survival (OS) (HR = 1.30, 95% CI 1.13 ~ 1.49, P < 0.0001). AR gene may be an important factor affecting the poor prognosis of GC patients of different genders. Keywords Androgen receptor . Gastric cancer . GEO database . TCGA database . Meta-analysis
Introduction GC is a common gastrointestinal cancer, its incidence ranks fifth, but the mortality rate ranks third [1]. It is a kind of disease with a complex etiology, which is closely related to living habits and environmental factors, such as lack of fresh vegetable and fruit, high salt diet, large amount of alcohol intake, smoking, and helicobacter pylori infection [2]. In addition, genetic and non-genetic changes in cancer-
Huafu Li and Zhewei Wei are joint first authors * Yulong He [email protected] * Changhua Zhang [email protected] 1
Digestive Diseases Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, No.628, Zhenyuan Rd, Shenzhen, Guangming (New) District, People’s Republic of China
2
Department of Gastrointestinopancreatic Surgery, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan 2nd Road, Guangzhou 510080, Guangdong, People’s Republic of China
related genes play an major role in the progress of GC [3]. Some gene changes, such as ERBB2, PTEN, FGF, TP53, CDH1, and cMET genes, have been reported and applied in clinical diagnosis and treatment of GC [4]. Gastric cancer, liver cancer, and pancreatic cancer are male-dominated cancers. Given this significant gender difference, there have been some studies on the effects of androgen receptors on these tumors [5]. The results of these studies indicate that AR gene expression and function is an important factor affecting these sex-dominant tumors, which also implies the importance of AR. Some studies have shown that AR also has a role in androgen-dependent and nonandrogen-dependent tumors [6]. For example, overexpression of AR gene can promote the high tumorigenicity of HCC, which also explains gender differences in HCC [5]. However, little is known about the differential mechanism of gastric cancer. Gender d
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