Impact of chronic kidney disease on long-term outcome of patients with valvular heart defects
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NEPHROLOGY - ORIGINAL PAPER
Impact of chronic kidney disease on long‑term outcome of patients with valvular heart defects Łukasz Kuźma1 · Jolanta Małyszko2 · Hanna Bachórzewska‑Gajewska1,3 · Marta Maria Niwińska1 · Anna Kurasz1 · Małgorzata Zalewska‑Adamiec1 · Marcin Kożuch1 · Sławomir Dobrzycki1 Received: 19 April 2020 / Accepted: 29 June 2020 © The Author(s) 2020
Abstract Introduction Valvular heart diseases (VHD) are becoming a significant problem in the Polish population. Coexistence of chronic kidney disease (CKD) in patients with VHD increases the risk of death and affects further therapeutic strategy. Aim Analysis impact of CKD on long-term prognosis in patients with VHD. Material and methods The inclusion criteria were met by 1025 patients with moderate and severe VHD. Mean observation time was 2528 ± 1454 days. Results The average age of the studied population was 66.75 (SD = 10.34), male gender was dominant 56% (N = 579). Severe aortic valve stenosis (AVS) occurred in 28.2%, severe mitral valve insufficiency (MVI) in 20%. CKD occurred in 37.1% (N = 380) patients mostly with mitral stenosis (50%, N = 16) and those with severe MVI (44.8%, N = 94). During the observational period, 52.7% (N = 540) deaths were noted. Increased risk of mortality was associated mostly with age (OR: 1.02, 95% CI: 1.00–1.03, p
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