Impact of COVID-19 on neurological manifestations: an overview of stroke presentation in pandemic
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COVID-19
Impact of COVID-19 on neurological manifestations: an overview of stroke presentation in pandemic Nida Fatima 1
&
Maher Saqqur 2 & Fatima Qamar 3 & Samia Shaukat 4 & Ashfaq Shuaib 5
Received: 3 June 2020 / Accepted: 1 August 2020 # Fondazione Società Italiana di Neurologia 2020
Abstract Corona virus disease 2019 (COVID-19) pandemic has become a globally challenging issue after its emergence in December 2019 from Wuhan, China. Despite its common presentation as respiratory distress, patients with COVID19 have also shown neurological manifestation especially stroke. Therefore, the authors sought to determine the etiology, underlying risk factors, and outcomes among patients with COVID-19 presenting with stroke. We conducted a systematic review of the electronic database (PubMed, Google Scholar, Scopus, Medline, EMBASE, and Cochrane library) using different MeSH terms from November 2019 to June 2020. A total of 39 patients with stroke from 6 studies were included. The mean age of our included patients was 61.4 ± 14.2 years. Majority of the patients (n = 36, 92.3%) with COVID-19 had ischemic stroke, 5.1% (n = 2) had hemorrhagic stroke, and 2.6% (n = 1) had cerebral venous thrombosis at the time of initial clinical presentation. Almost all of the patients presented had underlying risk factors predisposing to stroke which included diabetes mellitus, hyperlipidemia, hypertension, and previous history of cerebrovascular disease. 51.2% (n = 20) of the included patients infected with COVID-19 with stroke died, while remaining patients were either discharged home or transferred to a rehabilitation unit. Exploring the neurological manifestation in terms of stroke among patients with COVID-19 is a step towards better understanding of the virus, preventing further spread, and treating the patients affected by this pandemic. Keywords COVID-19 . Corona virus . Pandemic . Stroke . Neurological disorders
Abbreviations SARS-CoV-2 COVID-19 ACE PRISMA
Introduction Severe acute respiratory syndrome coronavirus 2 Corona virus disease 2019 Angiotensin-converting enzyme Preferred Reporting Items for Systematic Review and Meta-analysis
* Nida Fatima [email protected]
Severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) pandemic has emerged as an unprecedented global crisis. In the tremendous flow of viral pneumonia and lifethreatening respiratory complications, the influence of corona virus disease 2019 (COVID-19) on neurological diseases
1
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
2
Department of Neurology, University of Toronto Mississauga, Mississauga, Ontario, Canada
3
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
4
Department of Medicine, King Edward Medical University, Lahore, Pakistan
5
Department of Neurology, University of Alberta, Edmonton, Alberta, Canada
Maher Saqqur [email protected] Fatima Qamar [email protected] Samia Shaukat [email protected] Ashfaq Shuaib [email protected]
Neurol Sci
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