Impact of IL28B gene polymorphism on efficacy and safety of direct acting antivirals in hepatitis C Egyptian patients
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RESEARCH ARTICLE
Impact of IL28B gene polymorphism on efficacy and safety of direct acting antivirals in hepatitis C Egyptian patients Abdel‑Hameed Ibrahim Mohamed Ebid1 · Ossama Ashraf Ahmed2 · Sara Hassan Agwa3 · Sara Mohamed Abdel‑Motaleb1 · Radwa Samir Hagag4 Received: 19 February 2020 / Accepted: 11 June 2020 © Springer Nature Switzerland AG 2020
Abstract Background Hepatitis C virus infection is one of the major causes of liver cirrhosis and hepatocellular carcinoma worldwide. IL28B gene polymorphism has a direct relation to the response of interferon-based regimens. However, the effect of IL28B gene polymorphism on efficacy of the new direct acting antivirals used in treatment of chronic hepatitis C Egyptian patients hasn’t been studied yet. Objective This study aimed to investigate the frequency of IL28B genotypes and impact of its polymorphism on the efficacy and safety of two direct acting antiviral regimens. Setting Patients were recruited form faculty of Medicine Ain shams research institute, Cairo, Egypt. Methods Easy to treat chronic hepatitis C Egyptian patients were included in this prospective study. Patients were randomized into two groups, group 1 received sofosbuvir plus daclatasvir and group 2 received paritaprevir, ombitasvir and ritonavir plus ribavirin. Both treatment regimens were given for 3 months. Laboratory evaluation and IL28B rs 12979860 genotyping were performed at baseline. Follow ups were performed monthly. Fibrosis was assessed at baseline and after treatment. Main outcome measures The frequency of IL28B genotypes and their correlation with safety and efficacy of direct acting antiviral regimens. Results CT genotype was present in 52.42% of patients while CC and TT genotypes were present in 28.16% and 19.42% of patients, respectively. IL28B genotypes weren’t correlated to sustained virologic response in both treatment groups. Baseline fibroscan scores didn’t show any significant relations with IL28B genotypes. Aspartate aminotransferase/alanine aminotransferase ratio increased significantly at the end of treatment in group1. CC genotype had shown higher ratio values at the end of treatment in Group 2. Conclusion CT genotype is the predominant genotype in easy to treat HCV Egyptian patients. IL28B genotypes hasn’t any predictive value on the efficacy or the safety of direct acting antiviral regimens. Keywords Aspartate aminotransferase platelet ratio index · Chronic hepatitis C · Direct acting antivirals · IL28B genotypes · Sustained virologic response
Impacts on practice • CT genotype is the predominant genotype in easy to treat
HCV Egyptian patients.
* Radwa Samir Hagag [email protected] 1
• IL28B CC genotype has shown higher levels of AST/
ALT ratio at the 12th week of treatment with ombitasvir, paritaprevir, ritonavir plus ribavirin regimen.
Department of Pharmacy Practice, Faculty of Pharmacy, Helwan University, Cairo, Egypt
2
Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Introduction
3
Department of Cl
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