Impact of Infection on Transplant Outcomes: Transplant Infectious Disease Expertise as an Essential Component of Transpl
Infectious complications are a major cause of morbidity and mortality in both solid organ and hematopoietic stem cell transplant patients. The risk of infection by common opportunistic pathogens like cytomegalovirus can be mitigated with the optimal use o
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Contents Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . The Essential Role of Infectious Disease Specialists in the Care of Transplant Patients . . . . . . . . Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Abstract
Infectious complications are a major cause of morbidity and mortality in both solid organ and hematopoietic stem cell transplant patients. The risk of infection by common opportunistic pathogens like cytomegalovirus can be mitigated with the optimal use of molecular diagnostics and antiviral prophylaxis. Novel and emerging bacterial, viral, fungal, and parasitic pathogens may be more successfully managed with early diagnosis and therapy. In the care of solid organ and hematopoietic stem cell transplant candidates and recipients, involvement of physicians with expertise in transplant infectious diseases has been shown to improve outcomes. In addition to their essential role in decreasing patient morbidity and mortality, infectious disease specialists also add value to the transplant program through the development and implementation of infection prevention protocols. These specialists are on the front line of the response to new organisms that may present atypically or be difficult to recognize in patients receiving immunosuppressive therapies pre- and post-transplant. In this rapidly changing field, the Emerging Transplant Infections textbook provides updated information on the diagnosis, treatment, and prevention of significant infections often seen in this highly immunocompromised population.
M. I. Morris (*) Immunocompromised Host Service, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, FL, USA e-mail: [email protected] © Springer Nature Switzerland AG 2020 M. I. Morris et al. (eds.), Emerging Transplant Infections, https://doi.org/10.1007/978-3-030-01751-4_1-1
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M. I. Morris
Keywords
Transplant infectious diseases · Immunocompromised host · Value · Electronic consultation
Introduction As an introduction to this textbook focused on emerging transplant infections, it is appropriate to begin with the emergence of the burgeoning field of transplant infectious diseases. Outcomes for both solid organ and hematopoietic stem cell transplantation have improved with the development of safer and more effective immunosuppression. Techniques in organ procurement and preservation as well as methods for hematopoietic stem cell harvest and infusion have evolved, contributing to significant expansion in the availability and safety of transplant. As transplant procedures have become more
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