Impact of retrieved lymph node count on short-term complications in patients with gastric cancer
- PDF / 527,299 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 102 Downloads / 182 Views
(2020) 18:224
RESEARCH
Open Access
Impact of retrieved lymph node count on short-term complications in patients with gastric cancer Feng Sun†, Song Liu†, Peng Song†, Chen Zhang, Zhijian Liu, Wenxian Guan*
and Meng Wang*
Abstract Background: It is well established that retrieved lymph node (RLN) counts were positively correlated with better overall survival in gastric cancer (GC). But little is known about the relationship between RLN count and short-term complications after radical surgery. Methods: A total of 1487 consecutive GC patients between January 2016 and December 2018 at Nanjing Drum Tower Hospital were retrospectively analyzed. Univariate analyses were performed to elucidate the association between RLN count and postoperative complications. We further identified clinical factors that might affect the RLN count. Results: Among all of the patients, postoperative complications occurred in 435 (29.3%) patients. The mean RLN count was 25.1, and 864 (58.1%) patients were diagnosed with lymph node metastasis. Univariate analyses showed no significant difference between RLN count and postoperative complications (both overall and stratified by CDC grade). Univariate and multivariate analyses further revealed that type of resection, tumor invasion, and lymph node metastasis were associated with RLN count. Conclusions: The current study demonstrated that RLN count was not associated with postoperative short-term complications following gastrectomy of GC, which provided a rationale for the determination of a proper RLN count of curative gastrectomy. Keywords: Retrieved lymph nodes, Postoperative complications, Gastric cancer
Background There are approximately one million new cases of gastric cancer (GC) each year worldwide, and half of them occur in Eastern Asia, including China, Japan, and South Korea [1]. Despite advances in early screening and comprehensive treatment of GC, it remains the third most common cause of cancer-related death in the world [2]. For advanced GC, a consensus has been reached of radical gastrectomy with D2 lymphadenectomy [3]. However, there * Correspondence: [email protected]; [email protected] † Feng Sun, Song Liu and Peng Song contributed equally to this work. Department of Gastrointestinal Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China
is still controversy over the number of retrieved lymph nodes (RLNs) for accurate pathological staging. Several studies have reported that RLN count was positively correlated with better overall survival in GC, even in lymph node-negative GC [4–7]. An RLN count of ≥ 16 has been recommended by the 8th edition TNM classification for GC to guarantee the accurate pN stage [8]. Moreover, Okajima et al. suggested an optimal RLN count of ≥ 25 for nodal staging [9]. Recently, by stratum analysis of 7620 patients, Deng et al. proposed an optimal RLN count of ≥ 16 for lymph node-negative GC and > 30 for lymph node-positive GC [10]. These above studies are all conducted by comparing the
Data Loading...
