Impact of the donor-recipient gender matching on the graft survival from live donors
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RESEARCH ARTICLE
Open Access
Impact of the donor-recipient gender matching on the graft survival from live donors Gholamhossein Naderi1, Amin Azadfar1, Seyed Reza Yahyazadeh1*, Fatemeh Khatami2 and Seyed Mohammad Kazem Aghamir2*
Abstract Background: Several factors such as recipient age, BMI, serum cratinine, and positive history of dialysis are important in predicting graft survival among kidney transplant recipients. One factor affecting the transplant outcomes is donors and recipients gender, which is usually ignored. Methods: A total of 1113 kidney transplant recipients were studied in this retrospective cohort study. Several factors were taken into account for graft survival and outcomes such as donors and recipients gender and age in addition to common recipient factors like cratinine, eGFR, BMI, and positive history of dialysis. Results: The most successful transplant based on donor-recipient gender was observed in male donor to male recipient, and then male donor to female recipient. In female transplant recipients, level of serum cratinine and eGFR, positive dialysis history before transplant, and low donor hemoglobin level can be considered as good prognostic factors recommended for kidney transplant survival. Conclusions: Our results suggested gender matching for kidney transplant. Only in some exceptional conditions, male donor to female recipient kidney transplant may be successful and female donors to male recipients are not suggested, especially in aged patients with the history of dialysis. Keywords: Kidney transplant, Gender match, Survival, Dialysis
Introduction For most patients with end-stage renal disease (ESRD), the only treatment strategy is renal transplantation. Kidney transplantation has become a better cost-effective alternative to dialysis as a result of several improvements in early graft survival and long-term graft function. The first kidney transplantation was performed about half a century ago in which the transplant was performed from a live donor to his identical twin. After that, the concept of living and non-living unrelated donor resulted in increasing the number of organ donation in ESRD, and the number of kidney transplantations has escalated over the last ten years. More than two thousand kidney * Correspondence: [email protected]; [email protected] 1 Shariati Hospital, Department of Urology, Tehran University of Medical Sciences, Tehran, Iran 2 Urology research Center, Hassan Abad Sq., Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
transplants have been reported in Iran, among which 50% were deceased (brain death) cases. Several factors may have an impact on patients and/or graft survival, and also on transplant outcomes. Donor factors such as age, female gender, brain death of cerebrovascular cause, and prolonged criteria donor status had a noteworthy effect on the renal graft function [1–3]. Both recipient and donor Gender is one of the candidate elements that can better determine the graft outcomes, and also the gender match is suggested.
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