Implication of T Helper Cytokines in Contact Dermatitis and Atopic Dermatitis
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Contact Dermatitis (A Gimenez-Arnau, Section Editor)
Implication of T Helper Cytokines in Contact Dermatitis and Atopic Dermatitis Perrine Cochez, PhD1 Mathilde Choteau, PhD1 Nisha Limaye, PhD1 Marie Baeck, MD, PhD2,3 Laure Dumoutier, PhD1,4,* Address 1 de Duve Institute, Université Catholique de Louvain, Brussels, Belgium 2 Department of Dermatology, Cliniques universitaires Saint-Luc, Brussels, Belgium 3 Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium *,4 de Duve Institute, Avenue Hippocrate 74, B-1200, Brussels, Belgium Email: [email protected]
* Springer Nature Switzerland AG 2020
This article is part of the Topical Collection on Contact Dermatitis Keywords Contact dermatitis I Atopic dermatitis I Cytokines I T helper cells
Abstract Purpose of review Cytokines play a key role in lesion development in inflammatory skin diseases such as contact dermatitis and atopic dermatitis and are of great interest as therapeutic targets. This is reflected in the increasing number of clinical studies and case reports as well as preclinical mouse models that provide substantial data on the participation of cytokines in these pathologies. In this review, we provide a detailed and comprehensive account of the advances in the field. Recent results The importance and therapeutic potential of Th2 cytokines in allergic contact dermatitis (ACD) and atopic dermatitis (AD) are well documented. Recent results have added another member, IL-24, to the list of key players in both diseases. In addition, IL-9, which is associated with Th9 cells, has been found to be strongly increased in ACD patients, opening up another promising new avenue. Summary In this review, we describe the expression and role of Th cytokines in skin inflammatory disorders, based on mouse models and existing therapy, focusing on cytokines associated with different subpopulations of T helper cells.
Contact Dermatitis (A Gimenez-Arnau, Section Editor)
Introduction The term “eczema” encompasses several distinct types of skin conditions including contact dermatitis and atopic dermatitis. Contact dermatitis is a localized skin reaction caused by contact with a foreign agent, with symptoms generally limited to the contact site. It is divided into two types: irritant contact dermatitis (ICD) that accounts for 80% of contact dermatitis and allergic contact dermatitis (ACD). Contact dermatitis is mainly an occupational hazard, for example, in healthcare workers and hairdressers who most often present with eczema on the hands. Atopic dermatitis (AD) is a chronic inflammatory relapsing condition that appears in patients with genetic predisposition. Lesions affect different parts of the body with a pattern that can change with age and time. AD is due to epidermal barrier dysfunction as well as immune tolerance dysfunction. The patients present increased transepidermal water loss (TEWL) with dry skin, pruritus, and chronic eczema and are more susceptible to microbes such as Staphylococcus aureus, fungi,
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