Incidence of primary vesicoureteral reflux in patients with febrile convulsions

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Incidence of primary vesicoureteral reflux in patients with febrile convulsions Ahmet Midhat Elmacı 1 & Muhammet İrfan Dönmez 2

&

Melike Emiroğlu 3

Received: 29 July 2019 / Accepted: 30 October 2019 # Fondazione Società Italiana di Neurologia 2019

Abstract The aim of this study is to evaluate the incidence of vesicoureteral reflux (VUR) in patients with febrile convulsion (FC). For this, patients that were diagnosed with FC in 2018 were retrospectively reviewed. Those with epilepsy, motor/mental retardation, or spina bifida were excluded. Mid-stream urine samples were collected in children who were toilet trained while sterile bags were used in the smaller. Urinary tract infection (UTI) was defined as ˃ 5 leucocytes/HPF in urinalysis and a subsequent positive urine culture (≥ 10.000 CFU/ml). Children with UTI were further investigated via voiding cystourethrogram (VCUG) and dimercaptosuccinic acid (DMSA) scintigraphy for VUR. Urinalysis was present in 79 among a total of 181 patients (43.6%). Forty-five of the patients were male (57%). Mean age was 2.6 ± 1.4 years. UTI was diagnosed in 6 (7.6%) patients (5 females, 1 male). Three of the girls had recurrent febrile UTI and subsequently, VUR was diagnosed in two of them. VUR is found in 2.5% of the FC cases with urine sampling. Urinalysis should not be ignored in patients with FC as it may lead to diagnosis of VUR. Keywords Febrile convulsion . Fever . Urinary tract infection . Vesicoureteral reflux

Introduction Febrile convulsions (FC) are the most common cause of seizures during childhood and have an incidence of 2–5% in children 6 months to 5 years of age1. In definition, patients should have body temperature > 38oC and there should be no signs of an intracranial event or electrolyte imbalance 1. Etiology is multifactorial and it is thought to be the result of increased susceptibility of the central nervous system to fever.

* Muhammet İrfan Dönmez [email protected] Ahmet Midhat Elmacı [email protected] Melike Emiroğlu [email protected] 1

Pediatric Nephrology, Dr. Ali Kemal Belviranlı Women’s Maternity and Children’s Hospital, Konya, Turkey

2

Pediatric Urology, Konya Training and Research Hospital, Hacışaban Mahallesi, Yeni Meram Cd. No: 97, 42090, Meram, Konya, Turkey

3

Department of Pediatrics, Division of Pediatric Infectious Diseases, Selcuk University Faculty of Medicine, Konya, Turkey

Reports indicate viral infections are the most common reason for FC 1, 2. On the other hand, urinary tract infections (UTI) are the second most common bacterial infections in children that have an increased incidence during infancy 3. Difficulties in obtaining urine samples, especially in the emergency room (ER) setting, prevent us to detect its true incidence. UTI has been found to be the cause of FC in 5–6.9% of the patients 4–6. However, there has been no study to date that looked into the incidence of vesicoureteral reflux (VUR) that was diagnosed after a FC. The aim of this study is to evaluate the incidence of VUR in FC patients.

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