Increased leukotriene B4 plasma concentration in type 2 diabetes individuals with cardiovascular autonomic neuropathy
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Diabetology & Metabolic Syndrome Open Access
SHORT REPORT
Increased leukotriene B4 plasma concentration in type 2 diabetes individuals with cardiovascular autonomic neuropathy Jose Antonio Januario Neves1, Mozânia Reis De Matos1,2, Theresa Ramalho3, Daniele Pereira Santos‑Bezerra4, Cristiane Das Graças Dias Cavalcante2, Renata D’ Alpino Peixoto1, Márcia Silva Queiroz1, Sonia Jancar3 and Maria Lucia Correa‑Giannella1,4*
Abstract Background and aim: A low-grade inflammation is associated with cardiac autonomic neuropathy (CAN) and increased concentration of leukotriene B4 (LTB4) was found in individuals with type 1 diabetes and definitive CAN. This cross-sectional study evaluated plasma concentration of LTB4 and of other inflammatory mediators, namely, tumor necrosis factor (TNF), interleukin (IL)1B, and IL10 in individuals with type 2 diabetes (T2D) and different degrees of CAN, and correlated these inflammatory mediators with the degree of glycemic control and with a surrogate marker of insulin resistance. Methods: TNF, IL1B, IL10 and LTB4 plasma concentrations were measured in 129 T2D subjects (62% women with [median] age of 63 years, disease duration of 8 years and HbA1c of 7.3%) with or without CAN. The Lipid accumulation product index was used as a surrogate marker of insulin resistance. Results: LTB4 concentration was significantly higher in those presenting incipient CAN (69.7 ± 16.6 pg mL-1) and definitive CAN (71.5 ± 15.7 pg mL-1) versus those without CAN (57.0 ± 13.9 pg mL-1). The groups without CAN and with incipient CAN were pooled (group without definitive CAN) and compared to those with definitive CAN. LTB4 concen‑ tration was higher in the latter group, as well as TNF concentration, while IL10 concentration was lower in this group. After adjustment for confounding variables, only LTB4 concentration remained significantly different between the groups with and without definitive CAN. Plasma concentration of LTB4 did not correlate with the degree of glycemic control. After sorting the participants by sex, a borderline weak correlation was found between LTB4 and the Lipid accumulation product index in women. Conclusion: In the T2D setting, circulating LTB4 concentration seems to be associated with cardiovascular dysautonomia. Keywords: LTB4, Chronic diabetes complications, Inflammation, Insulin resistance
*Correspondence: [email protected] 1 Programa de Pos‑Graduação Em Medicina, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 235, 2° subsolo, Pos‑graduação, Sao Paulo CEP: 01504‑001, Brazil Full list of author information is available at the end of the article
Background Chronic low-grade inflammation is present in obesity, being closely associated with the etiopathogenesis of insulin resistance and, consequently, with type 2 diabetes mellitus (T2D). Among the pro-inflammatory cytokines produced by the adipose tissue in visceral obesity are tumor necrosis factor (TNF), interleukin (IL) 1B and IL6.
© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0
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