Induced Pluripotent Stem Cell-Derived Vascular Smooth Muscle Cells for Vascular Regeneration
Vascular smooth muscle cells (VSMCs) play a critical role during the development of blood vessels and cardiovascular disease progression. Although autologous VSMCs have been used in vascular tissue engineering, it would be desirable to have a renewable so
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Stem Cell Therapy for Vascular Diseases
Tulio Pinho Navarro Lara Lellis Navarro Minchillo Lopes Alan Dardik Editors
Stem Cell Therapy for Vascular Diseases State of the Evidence and Clinical Applications
Editors Tulio Pinho Navarro Department of Surgery Vascular Surgery Section Federal University of Minas Gerais Belo Horizonte Minas Gerais Brazil
Lara Lellis Navarro Minchillo Lopes Postgraduate Program in Sciences Applied to Surgery Federal University of Minas Gerais Belo Horizonte Minas Gerais Brazil
Alan Dardik Vascular Biology and Therapeutics Program and the Departments of Surgery and Cellular and Molecular Physiology Yale University School of Medicine New Haven, CT USA
ISBN 978-3-030-56953-2 ISBN 978-3-030-56954-9 (eBook) https://doi.org/10.1007/978-3-030-56954-9 © Springer Nature Switzerland AG 2021 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Despite major medical and scientific advances in the last 50 years, vascular disease continues to challenge us. Aneurysms, atherosclerosis, heart failure, stroke, malformations, fistulae, and vasculitis all continue to provide diagnostic and therapeutic challenges that keep vascular disease the leading the cause of death and a major source of morbidity and suffering in modern society. Physicians and surgeons continue to treat vascular disease with the technology at hand. Early advances with cautery and suture have been supplemented by stents, wires, and coils to give modern practitioners a range of therapeutic options. But there is still room to improve. What is next? It is likely to be exciting. Understanding the biology of stem cells has been a tremendous advance in modern medicine and has captured the imagination
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