Inflammation as a Mechanism of Bipolar Disorder Neuroprogression
Bipolar disorder (BD) is a severe, debilitating psychiatric condition with onset in adolescence or young adulthood and often follows a relapsing and remitting course throughout life. The concept of neuroprogression in BD refers to the progressive path wit
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Contents 1 Introduction 2 Evidence of Inflammatory and Infectious Diseases in BD Neuroprogression
T. Barichello (*) Translational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil Neuroscience Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA e-mail: [email protected] V. V. Giridharan, G. Bhatti, P. Sayana, and T. Doifode Translational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA D. Macedo Neuropsychopharmacology Laboratory, Drug Research, and Development Center, Faculty of Medicine, Universidade Federal do Ceará, Fortaleza, CE, Brazil National Institute for Translational Medicine (INCT-TM, CNPq), Ribeirao Preto, Brazil J. Quevedo Translational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA Neuroscience Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA Laboratory of Neurosciences, Graduate Program in Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, SC, Brazil Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA © Springer Nature Switzerland AG 2020 Curr Topics Behav Neurosci https://doi.org/10.1007/7854_2020_173
T. Barichello et al. 2.1
Maternal Immune Activation as a Risk Factor for BD Development and Neuroprogression 2.2 Role of Infectious Disease as a Trigger to Develop BD Neuroprogression 2.3 Autoimmune Disorders and Their Association with BD Neuroprogression 2.4 Role of the Gut–Brain Axis on BD Neuroprogression 3 Inflammatory and Oxidative Mechanisms in BD Neuroprogression 3.1 Mechanisms of Inflammation and Their Contribution to BD Neuroprogression 3.2 Oxidative Stress and Mitochondrial Dysfunction Associated with BD Neuroprogression 3.3 Peripheral Inflammatory Mediators as a Trigger or Accelerator of BD Neuroprogression 3.4 Cerebrospinal Fluid (CSF) System Inflammatory Markers in BD Neuroprogression 3.5 Postmortem Inflammatory Markers in BD Neuroprogression 4 Conclusions and Future Directions References
Abstract Bipolar disorder (BD) is a severe, debilitating psychiatric condition with onset in adolescence or young adulthood and often follows a relapsing and remitting course throughout life. The concept of neuroprogression in BD refers to the progressive path with an identifiable
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