Inflammatory plasma biomarkers of abdominal aortic aneurysms
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Hellenic Journal of Surgery (2014) 86:5, 296-301
Inflammatory Plasma Biomarkers of Abdominal Aortic Aneurysms V. Martinakis, G. Galyfos, F. Sigala, I. Andreadou, G. Zografos, K. Filis
Abstract Aim-Background: Osteopontin (OPN) and osteoprotegerin (OPG) have been implicated in the development and progression of atherosclerosis. We studied the correlation of these two molecules with abdominal aortic aneurysm (AAA) in terms of its development and extent, and present our preliminary results. Methods: Osteopontin and osteoprotegerin serum values in 74 patients with AAA were compared with the corresponding values of 20 patients (control group) who had similar characteristics and no AAA. All aneurysms were classified as Types A-E, according to their anatomical extent as seen on CT imaging (EUROSTAR criteria). Results: Our results showed that osteopontin values were higher in patients with any type of aneurysm (OPN:
3661.64 ± 1126.49ng/ml) compared to the control group (OPN: 1418.30 ± 962.68ng/ml; p = 0.017, Types A-B: p = 0.03, Types C-E: p = 0.01). Osteopontin and osteoprotegerin values did not differ among aneurysms of different extent. Osteoprotegerin values of patients with any type of aneurysm (OPG: 354.28 ± 212.1ng/ml) and of controls (OPG: 364.87 ± 159.85ng/ml) showed no significant difference. Conclusions: Serum osteopontin may be a potential independent biomarker for AAA development, although it is
not associated with the extent of the aneurysm. Serum osteoprotegerin seems to be of less prognostic value. The role of their levels concerning treatment of AAA remains questionable and needs further research. Key words: Osteopontin, osteoprotegerin, abdominal aortic aneurysm, serum biomarkers
Introduction-Aim Abdominal aortic aneurysms (AAAs) affect approximately 5% of elderly men and represent a chronic degenerative disease associated with considerable morbidity and mortality [1,2]. Moreover, studies have shown that the incidence of ruptured AAAs in cases of sudden death ranges from 4% to 5% [3]. Although the associated clinical risk factors have been well documented, the exact pathophysiological mechanism of AAA development seems to be obscure. Furthermore, the increasing number of identified AAAs in an aging population, as recorded in ultrasound screening programmes, highlights a number
V. Martinakis, G. Galyfos, F. Sigala, G. Zografos, K. Filis 1st Department of Propedeutic Surgery, University of Athens Medical School, Ippokrateion Hospital, Athens, Greece I. Andreadou Department of Pharmaceutical Chemistry, University of Athens School of Pharmacy, Athens, Greece. Corresponding author: George Galyfos 6 Melinas Merkouri Street, Neon Iraklion, 14122, Athens, Greece Tel.: +30 6938764167, Fax: +30 210 7707574 e-mail: [email protected] Received 17 June 2014; Accepted 23 July 2014
Hellenic Journal of Surgery 86
of deficiencies in the current diagnosis and management of this condition. In consequence, many researchers have focused on the identification of novel biomarkers. Circulating markers could play a
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