Influenza A virus vaccine H1N1
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Allergic symptoms: 9 case reports A study identified eight women aged 33–55 years, and one 6-year-old girl, who developed allergic symptoms after vaccination with influenza A virus vaccine H1N1 [outcomes not stated]. The patients had developed allergic symptoms within 24 hours of receiving influenza A virus vaccine H1N1 [Arepanrix; drug details not stated]. Symptoms included chest and throat tightness, conjunctivitis, facial oedema, and dyspnoea. Three of the patients had received treatment including epinephrine, antihistamines and corticosteroids. After 13–18 months, skin prick and intradermal testing was conducted. Four patients had positive skin test results. Five patients developed allergic symptoms after seasonal revaccination; their skin test results were negative or indeterminate. Author comment: "IgE mediated allergies to the pandemic vaccine were rare and that reactions in our patients were either coincidental or attributable to other immunologic reactions to the vaccine that have yet to be determined." Rouleau I, et al. Allergic symptoms after pandemic influenza vaccination rarely mediated by vaccine-specific IgE. Journal of Allergy and Clinical Immunology 130: 1423-1426, No. 6, Dec 2012. Available from: URL: http://dx.doi.org/10.1016/ 803083695 j.jaci.2012.07.019 - Canada
0114-9954/10/1440-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 23 Feb 2013 No. 1440
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