Influenza protection may lower non-specific immunity
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Influenza protection may lower non-specific immunity Researchers from Hong Kong University show that, while the 2008–09 seasonal trivalent influenza inactivated vaccine [0.5mL Vaxigrip] appeared to provide school-aged children with protection against the seasonal influenza viruses that circulated in January–March 2009, vaccine recipients were at a significantly increased risk of non-influenza respiratory virus infections during this time. A total of 115 children, aged 6–15 years, received either 0.5mL Vaxigrip or placebo in a double-blind, randomised controlled trial. Over the following 9 months, children who received the influenza vaccine were at a significantly higher risk of non-influenza respiratory virus infections compared with those who received placebo (risk ratio 3.46; 95% CI 1.19, 10.1). In particular, the risks of rhinovirus and coxsackie/ echovirus infections were significantly increased in vaccine recipients. These infections were most frequently detected in March 2009, immediately after the peak in seasonal influenza activity. The researchers conclude that children who receive the influenza vaccine may be protected against influenza, but may then lack temporary non-specific immunity to protect them against other respiratory viruses. Cowling BJ, et al. Increased risk of non-influenza respiratory virus infections associated with receipt of inactivated influenza vaccine. Clinical Infectious Diseases : 15 Mar 2012. Available from: URL: http://dx.doi.org/10.1093/cid/ 803068728 cis307
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Reactions 21 Apr 2012 No. 1398
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