Inhibitors, molecular and chemical
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IC50
now referred to as caspase 11. It is the mammalian homologue of Caenorhabditis elegans cell death protein Ced-3 and consists of two subunits of 22 kD (p20) and 10 kD (p10).
ICE-LAP3 Definition ! Caspase 7.
Definition IC50 is the molar concentration of a receptor ligand in a competition experiment between two ligands at which half of the agonist is bound to the receptor.
ICE-LAP6 Definition ! Caspase 9.
ICAM Definition Intercellular adhesion molecule (ICAM) is a specific cell surface protein involved in cell adhesion.
ICE
ICErel-II Definition ! Caspase 4.
ICF Syndrome
Definition
Definition
Interleukin-1b-converting enzyme (ICE) is a ! caspase that can process pro-interleukin-1b to mature interleukin-1b. It can also process interferon-c-inducing factor efficiently in vitro and in vivo. It was identified as the first member of the mammalian ! caspase gene family,
ICF stands for: immunodeficiency, centromeric instability and facial abnormalities. The ICF syndrome is an extremely rare autosomal recessive disorder. It is characterized by the presence of variable immunodeficiency, instability of the pericentromeric heterochromatin and decon-
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ICH
densation in chromosomes 1, 9 and 19, resulting in multibranched chromosomes and mild facial abnormalities; ! methylation.
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ICH Definition Interleukin-1 b converting enzyme family of cysteine proteases; belongs to apoptosis-related proteases. ICH-1, also ICH1; synonymes: NEDD2; CASP2, ! caspase 2. ICH-2, synonyms: CASP4, ! caspase 4.
Id Proteins Definition Inhibitor of DNA (Id) binding proteins are a family of related nuclear helix-loop-helix-proteins implicated in the control of differentiation and cell cycle progression. Id nuclear proteins interact with transcription factors and prevent them from binding to DNA. The primary targets of Id proteins are the basic helix-loop-helix (! bHLH) transcription factors, which regulate cell-type-specific gene expression and expression of cell cycle regulatory genes. Generally, they act as positive regulators of cell growth and as negative regulators of differentiation. Id proteins lack a basic DNA-binding domain, therefore heterodimers between Id and bHLH proteins cannot bind to DNA. This mode of regulation is referred to as dominant-negative. Id proteins act as dominant-negative antagonists of other helix-loop-helix transcription factors; Id1, Id2, Id3, Id4, ! E-box [Norton JD, Deed RW, Craggs G, Sablitzky F (1998) Id helixloop-helix proteins in cell growth and differentiation. Trends Cell Biol. 8: 58-65]. *
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Id1, inhibitor of DNA binding 1, is a protein of 154 aa and 16 kD. The gene maps to chromosome 20 band q11. Id2, inhibitor of DNA binding 2, is a protein of 134 aa and 14 kD. It is expressed in most
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early fetal tissues but not in the corresponding mature tissues.The gene maps to 2p25. Id3, inhibitor of DNA binding 3, also known as Heir-1 is a protein of 119 aa and 12 kD. It is expressed abundantly in lung, kidney and adrenal gland, but lacking in adult brain. The gene maps to 1p36, a region frequent
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