Inkjet Printing of Biomedical Adhesives
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0950-D12-05
Inkjet Printing of Biomedical Adhesives Anand Doraiswamy1, Jan Sumerel2, Jonathan Wilker3, and Roger J Narayan1 1 University of North Carolina, Chapel Hill, NC, 27599-7575 2 Fujifilm Dimatix, 2230 Martin Avenue, Santa Clara, CA, 95050 3 Purdue University, West Lafayette, IN, 47907-2084 ABSTRACT Synthetic adhesives have largely displaced natural adhesives in the automotive, aerospace, biomedical, electronic, and marine equipment industries over the past century. We have demonstrated the thin film deposition of biological adhesives using piezoelectric inkjet technology. A MEMS based piezoelectric actuator was controlled to jet uniform fluid flow of the adhesive solution through the ink jet nozzles. Microscopic deposition of adhesives enables improved bonding for a range of advanced electronic and biomedical applications. By printing such small and spatially aligned drops, bond lines between materials are reduced, ultimately resulting in increased bond strength and structural integrity. Piezoelectric ink jet deposition of biological adhesives may greatly improve wound repair in next generation eye repair, fracture fixation, organ fixation, and wound closure. INTRODUCTION Ink-jet technology is non-contact printing process for processing materials [1, 2]. In thermal printing, a resistive element is used to heat the fluid, creating a bubble that forces the ink out of the nozzle. A similar process has been utilized for printing biomolecules such as proteins and various living cells [3-5]. However, the thermal stimulus does not entirely preclude damage to sensitive biological materials. Athermal ink-jet printing technologies, including syringe-solenoid and piezoelectric systems, have also been developed [6]. In a solenoid system, a syringe pump is used with a microsolenoid actuator to create controlled fluid flow across an orifice. However, high internal pressures can result in damage to the printer head. In a piezoelectric inkjet system, piezoelectric crystals are used to create mechanical vibrations to control fluid flow via the nozzle by the application of external voltage. Piezoelectric printers are categorized based on the deformation mode such as squeeze, bend, push and shear modes in the piezoelectric crystal [7]. The general principle of operation involves the creation of a rapidly moving stream of fluid that passes through a small nozzle. When a given linear velocity is reached by the fluid, it is ejected from the orifice as a droplet. Resolution of the printed features are dependent on several parameters, including fluid viscosity, surface tension, fluid-mass velocity, nozzle size, droplet size, and lateral resolution of the printer head. In this study, piezoelectric actuated ink-jet technology was used to develop CAD/CAM microscale patterns of biomedical adhesives.
EXPERIMENTAL DETAILS VetbondTM tissue adhesive (n-butyl cyanoacrylate) (Fisher Science, NJ, USA) and NexabandTM tissue adhesive (2-octyl cyanoacrylate) (Fisher Science, NJ, USA) were stored in the cartridge at a temperature of 28 oC. A p
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