Innovation and Biomedicine Ethics, Evidence and Expectation in HIV
With its focus on the offshore randomized control trials of a Pre-Exposure Prophylactic pill (PrEP) for preventing HIV infection, the volume develops a sustained analysis of the complex, virtual and topological dimensions of the expectations, ethics and e
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by Mike Michael THE SACRIFICE: How Scientific Experiments Transform Animals and People (with Lynda Birke and Arnold Arluke, 2007) 7 TECHNOSCIENCE AND EVERYDAY LIFE (2006) SCIENCE, SOCIAL THEORY AND PUBLIC KNOWLEDGE (with Alan Irwin, 2003) RECONNECTING CULTURE, TECHNOLOGY AND NATURE: From Society to Heterogeneity (2000) CONSTRUCTING IDENTITIES: The Social, the Nonhuman and Change (1996)
Also by Marsha Rosengarten HIV INTERVENTIONS: Biomedicine and the Traffic between Information and Flesh (2009)
Innovation and Biomedicine Ethics, Evidence and Expectation in HIV Mike Michael University of Sydney, Australia and
Marsha Rosengarten Goldsmiths, University of London, UK
© Mike Michael and Marsha Rosengarten 2013 Softcover reprint of the hardcover 1st edition 2013 978-0-230-30267-9 All rights reserved. No reproduction, copy or transmission of this publication may be made without written permission. No portion of this publication may be reproduced, copied or transmitted save with written permission or in accordance with the provisions of the Copyright, Designs and Patents Act 1988, or under the terms of any licence permitting limited copying issued by the Copyright Licensing Agency, Saffron House, 6–10 Kirby Street, London EC1N 8TS. Any person who does any unauthorized act in relation to this publication may be liable to criminal prosecution and civil claims for damages. The authors have asserted their rights to be identified as the authors of this work in accordance with the Copyright, Designs and Patents Act 1988. First published 2013 by PALGRAVE MACMILLAN Palgrave Macmillan in the UK is an imprint of Macmillan Publishers Limited, registered in England, company number 785998, of Houndmills, Basingstoke, Hampshire RG21 6XS. Palgrave Macmillan in the US is a division of St Martin’s Press LLC, 175 Fifth Avenue, New York, NY 10010. Palgrave Macmillan is the global academic imprint of the above companies and has companies and representatives throughout the world. Palgrave® and Macmillan® are registered trademarks in the United States, the United Kingdom, Europe and other countries
ISBN 978-1-349-33770-5 ISBN 978-1-137-31667-7 (eBook) DOI 10.1057/9781137316677 This book is printed on paper suitable for recycling and made from fully managed and sustained forest sources. Logging, pulping and manufacturing processes are expected to conform to the environmental regulations of the country of origin. A catalogue record for this book is available from the British Library. A catalog record for this book is available from the Library of Congress.
Contents
Acknowledgements
vi
1
Introduction: Setting a Scene
1
2
A Brief and Partial History of Randomized Controlled Trials (RCTs) in the Context of HIV Prevention and Treatment
18
3
Theory and Event: Approaching the Study of PrEP
45
4
The Gold Standard: The Complex Singularity of PrEP, RCT and Bioethics
70
5
PrEPs, Multiplicity and the Qualification of Knowledge and Ethics
106
6
On Some Topologies of PrEP
135
7
Conclusion: Eventuating the Methodology of Trials
15
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