Innovation in pharmaceutical R&D: mapping the research landscape
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Innovation in pharmaceutical R&D: mapping the research landscape Angelo Kenneth S. Romasanta1,2 · Peter van der Sijde1 · Jacqueline van Muijlwijk‑Koezen2 Received: 1 November 2018 / Accepted: 2 September 2020 © The Author(s) 2020
Abstract In response to the increasing number and breadth of innovation studies on the pharmaceutical industry, we mapped the literature to show the trends in recent research and to indicate areas for further research. In the first phase, we analyzed articles on the pharmaceutical industry published in innovation journals. We used these articles’ textual and citation data and applied hybrid cluster analysis. Three main clusters were produced based on the level of analysis innovation scholars had used to investigate the industry: macro, meso and micro. We describe the research topics within these clusters and show that, overall, innovation scholars increasingly focus on the meso-level, analyzing the relationships across different firms. This shift in interest toward the collaborative nature of drug discovery and development was also apparent in macro- and micro-level studies. To explore how this literature is used by scientists in the industry, our second phase involved analysis of the citing articles published in pharmaceutical journals. Using our findings, we propose research areas that can be further explored in order to create an engaged and better-integrated literature on pharmaceutical innovation. Keywords Pharmaceutical industry · Drug development · Innovation · Research and development
Introduction Innovation is an important issue for the pharmaceutical industry, especially with regard to bringing new drugs to the market (e.g. Achilladelis and Antonakis 2001; Bianchi et al. 2011). Hundreds of studies on the industry are published each year, exploring the different trends and challenges in innovation in the industry (e.g. Bianchi et al. 2011; Bierly and Chakrabarti 1996; Malerba and Orsenigo 2015; Rafols et al. 2014; Tierney et al. 2013). Despite the increasing number of publications, there have been no efforts to map * Angelo Kenneth S. Romasanta [email protected] 1
Science, Business and Innovation, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
2
Amsterdam Institute of Molecules, Medicines and Systems (AIMMS), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Vol.:(0123456789)
Scientometrics
this literature. Without such overviews, it can be difficult to navigate the wide range of studies published on this industry and thus discern the direction the literature is taking. We therefore mapped the various innovation topics explored in the industry and identified areas for further research. Such a study is an important first step towards a coherent and better-engaged literature on pharmaceutical innovation. In an earlier synthesis of the wider literature on innovation, Crossan and Apaydin (2010) found innovation to be both a process and an outcome related to the “production or adoption, assimilation, and exploitation of a value‐added novelty
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