Insertional Mutagenesis Strategies in Cancer Genetics
Over the past decades, insertional mutagenesis has played an important contribution to our understanding of cancer. Initially, the action of slow transforming retroviruses was used to identify endogenous cellular oncogenes (e.g. Myc, Myb). These observati
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Adam J. Dupuy · David A. Largaespada Editors
Insertional Mutagenesis Strategies in Cancer Genetics
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Editors Adam J. Dupuy Department of Anatomy & Cell Biology Carver College of Medicine University of Iowa Iowa City, IA 52242, USA
David A. Largaespada, Ph.D The Department of Genetics, Cell Biology & Development University of Minnesota Minneapolis, MN 55455, USA
ISBN 978-1-4419-7655-0 e-ISBN 978-1-4419-7656-7 DOI 10.1007/978-1-4419-7656-7 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010938734 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
1 Insertional Mutagenesis: A Powerful Tool in Cancer Research . . . . Anton Berns 2 Retroviral Insertional Mutagenesis in Mouse Models of Leukemia and Lymphoma . . . . . . . . . . . . . . . . . . . . . . . David A. Largaespada
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3 Gene Discovery by MMTV Mediated Insertional Mutagenesis . . . . Annabel Vendel-Zwaagstra and John Hilkens
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4 Chicken Models of Retroviral Insertional Mutagenesis . . . . . . . . Vladimír Peˇcenka, Petr Pajer, Vít Karafiát, and Michal Dvoˇrák
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5 Sleeping Beauty Models of Cancer . . . . . . . . . . . . . . . . . . . . Jesse D. Riordan, Laura M. Rogers, Katherine E. Berquam-Vrieze, and Adam J. Dupuy
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6 Insertional Mutagenesis in Hematopoietic Cells: Lessons Learned from Adverse Events in Clinical Gene Therapy Trials . . . . Lars U. Müller, Michael D. Milsom, and David A. Williams
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7 Bioinformatics of High-Throughput Insertional Mutagenesis . . . . . Keiko Akagi, Ming Yi, Jean Roayaei, and Robert M. Stephens
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Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Contributors
Keiko Akagi Mouse Cancer Genetics Program, National Cancer Institute, Center for Cancer Research, Frederick, MD 21702, USA; Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA, keiko.akagi@o
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